| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Many eukaryotic genes are interrupted by introns that are removed from primary transcripts by RNA splicing. U1 snRNP plays a crucial role in the 5' splice site recognition during splicing. Recently, we found the first example of naturally-occurring U1-independent U2-type splicing in humans. Our present study showed that a tissue-specific splicing regulator, Fox-1, failed to induce hF1γexon 9 skipping if the 5' splice site of intron 9 was mutated to the U1-dependent type, suggesting that U1-independent splicing contributes to the regulation of alternative splicing of a class of pre-mRNAs.
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