| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
By using genome sequence alignments, We have identified many non-coding motifs that are conserved among mammalian species. For these motifs, we mainly focused on the cis-regulatory elements that regulate splicing. As the results, we revealed the existence of a network of cis-regulatory elements to achieve complicated regulations of alternative splicing. Extending this methodology to the identification of transcription factor binding sites, and to analyze the relationships between these motifs and single nucleotide polymorphisms(SNPs) are still under way. The computational environments and programs developed in this research project should facilitate further progress of these analyses in future.
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