Structure-activity relationship study of hatermalides by using medicinal chemistry
| Project/Area Number |
21510221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 天然物有機化学 / 有機合成化学 / 腫瘍細胞増殖阻害 / 構造活性相関 / ハテルマライド / ビセライド / 細胞毒性 / メディシナルケミストリー |
|---|
| Research Abstract |
Haterumalides and biselides are cytotoxic macrolide isolated from the Okinawan marine animals. Interestingly, haterumalide NA showed strong toxicity against brine shrimp, while haterumalide NA methyl ester and biselide A are less toxic. I planned to synthesize haterumalide derivatives and to evaluate its biological activity. As a result, I elucidated that chloroolefin part of haterumalides is essential for the strong cytotoxicity of haterumalides. Also, I have achieved the synthesis of core carbon framework of biselide E.
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Report
(4 results)
Research Products
(104 results)
