| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In the present study, we focused on two points;
1) Further analyses of the protein arginine methylation and the elucidation of intracellular processes of methyl arginine production.
2) Feto-placental-maternal pharmacokinetic monitoring of methyl arginines andrelated amines. In conclusion, we showed that the arginine methylationof DAF-16 regulates life-span of C. elegans and free-methylargines were generated through both ubiquitin-proteasome system and autophagosome system, and succeeded in identifications ofseveral amines involved in the feto-maternal chemical communications.
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