Analyses of methylarginines on the chemical communication between fetus and mother.
| Project/Area Number |
21510222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAKO Koichiro 筑波大学, 生命環境系, 講師 (60311594)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Junji 筑波大学, 生命環境系, 講師 (30323257)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アルギニンメチル化 / アミン / 高感度定量分析法 / ケミカルコミュニケーション / 生理活性アミン / メチル化アルギニン / 妊娠高血圧 / 質量分析法 / メチル化 / タンパク質アルギニンメチル化酵素 / 一酸化窒素合成酵素 |
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| Research Abstract |
In the present study, we focused on two points;
1) Further analyses of the protein arginine methylation and the elucidation of intracellular processes of methyl arginine production.
2) Feto-placental-maternal pharmacokinetic monitoring of methyl arginines andrelated amines. In conclusion, we showed that the arginine methylationof DAF-16 regulates life-span of C. elegans and free-methylargines were generated through both ubiquitin-proteasome system and autophagosome system, and succeeded in identifications ofseveral amines involved in the feto-maternal chemical communications.
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Report
(5 results)
Research Products
(35 results)
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[Journal Article] Asymmetric arginine dimethylation determines life span in C.elegans by regulating forkhead transcription factor DAF-162011
Author(s)
Takahashi Y., Daitoku H., Hirota K., Tamiya H., Yokoyama A., Kako K., Nagashima Y., Nakamura A., Shimada T., Watanabe S., Yamagata K., Yasuda K., Ishii N., Fukamizu A.
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Journal Title
Cell Metabolism
Volume: 13
Issue: 5
Pages: 505-516
DOI
Related Report
Peer Reviewed
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[Journal Article] Production of free methylarginines via the proteasome and autophagy pathways in cultured cells.2011
Author(s)
Shirakawa, T., Kako,K., Shimada, T., Nagashima, Y., Nakamura, A., Ishida, J.,Fukamizu, A.
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Journal Title
Mol. Med. Rep.
Volume: 4
Pages: 615-620
DOI
Related Report
Peer Reviewed
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