Elucidation of natural products to regulate glucose-transporters on the small intestine
| Project/Area Number |
21510223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
KOYAMA Tomoyuki 東京海洋大学, 大学院・海洋科学技術研究科, 准教授 (00377904)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生物活性物質 / 機能性食品素材 / マウス糖負荷試験 / 血糖値上昇抑制作用 / グルコース吸収抑制作用 / トランスポーター / 吸収阻害 / 単離・精製 / 構造決定 / 糖尿病予防 |
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| Research Abstract |
Through exploratory study of the food material to suppress postprandial elevation of blood glucose level in mice, this study aimed to find and identified compounds having inhibitory effect of glucose absorption from the intestinal tract. As a result, some inhibitors against carbohydrate digestive enzymes or against glucose-transport in the intestine were purified with chromatography and then identified by spectral analysis. Multiflorin A, which was obtained from peach leaf extract, showed the most powerful effect compared with known transporter-inhibitors. Then the study of structure-activity relationship showed that its acetyl group is important to express the activity in vivo.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Peach leaf contains multiflorin A as a potent inhibitor of glucose absorption in the small intestine in mice2012
Author(s)
Shirosaki, M., Goto, Y., Hirooka, S., Masuda, H., Koyama, T., Yazawa, K.
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Journal Title
Biol. Pharm. Bull
Volume: (accepted)
NAID
Related Report
Peer Reviewed
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