| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
A low-molecular-weight basement membrane protein AZ-1 was demonstrated to be a multivalent factor which interacted with structural extracellular matrix proteins, vascular endothelium growth factor(VEGF), VEGF-receptors, and integrins. The multivalent interactions allowed to modulate adhesion, growth, and tubular formation of endothelial cells. The processes may inhibit activation of the cells by VEGF and play a role for homeostasis of vascular endothelium.
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