Inhibitory action of a matricellular protein AZ-1 on vascular endothelium growth factor-receptor
| Project/Area Number |
21510229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
MUKAI Kuniaki 慶應義塾大学, 医学部, 講師 (80229913)
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| Co-Investigator(Kenkyū-buntansha) |
MITANI Fumiko 慶應義塾大学, 医学部, 講師(非常勤) (60041852)
NISHIMOTO Koshiro 慶應義塾大学, 医学部, 共同研究員 (00365363)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞・組織 / 生理活性 / 蛋白質 / シグナル伝達 / 生体分子 |
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| Research Abstract |
A low-molecular-weight basement membrane protein AZ-1 was demonstrated to be a multivalent factor which interacted with structural extracellular matrix proteins, vascular endothelium growth factor(VEGF), VEGF-receptors, and integrins. The multivalent interactions allowed to modulate adhesion, growth, and tubular formation of endothelial cells. The processes may inhibit activation of the cells by VEGF and play a role for homeostasis of vascular endothelium.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Transcriptome analysis reveals differentially expressed transcripts in rat adrenal zona glomerulosa and zona fasciculata2012
Author(s)
Nishimoto, K., Rigsby, C. S., Wang, T., Mukai, K., Gomez-Sanchez, C. E., Rainey, W. E., Seki, T
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Journal Title
Endocrinology
Volume: 153
Pages: 1755-1763
Related Report
Peer Reviewed
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[Journal Article] Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice2010
Author(s)
Tajiri, Y., Igarashi, T., Li, D., Mukai, K., Suematsu, M., Fukui, E., Yoshizawa, M., and Matsumoto, H
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Journal Title
Biol Reprod
Volume: 82
Pages: 263-270
Related Report
Peer Reviewed
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[Journal Article] Adrenocortical zonation in humans under normal and pathological conditions2010
Author(s)
Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M., and Mukai K
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Journal Title
J. Clin. Endocrinol. Metab
Volume: 95
Pages: 2296-2305
Related Report
Peer Reviewed
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[Journal Article] Tubulointerstitial nephritis antigen-like 1 is expressed in extraembryonic tissues and interacts with laminin 1 in the Reichert membrane at postimplantation2009
Author(s)
Igarashi, T., Tajiri, Y., Sakurai, M., Sato, E., Li, D., Mukai, K., Suematsu, M, Fukui, E, Yoshizawa, M, Matsumoto, H
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Journal Title
Biol Reprod
Volume: 81
Pages: 948-955
Related Report
Peer Reviewed
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