New natural compounds that inhibit development and hatching of echinoderm embryos.
| Project/Area Number |
21510235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagahama Institute of Bio-Science and Technology |
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Principal Investigator |
OHTA Shinji 長浜バイオ大学, バイオサイエンス学部, 教授 (60185270)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 天然物有機化学 / 生物活性物質 / 海綿 / ポリアセチレン / 胚発生 / ヒトデ / 発生阻害 / 孵化阻害 |
|---|
| Research Abstract |
New linear polyacetylene compounds designated petroacetylene and bromotheoynic acid have been isolated from the marine sponge Petrosia solida Hoshino 1981 and Theonella swinhoei, respectively, collected off the coast of Kagoshima Prefecture, Japan. The structures were elucidated on the basis of spectroscopic data and chemical means. We have evaluated the effects of the new polyacetylenes on development and hatching of echinoderm embryos.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] JBIR-14, a highly oxygenated ergostane, from Isaria sp. NBRC 1043532010
Author(s)
M. Takagi, J. Ueda, T. Kunoh, M. Sekigawa, S. Wada, Y. Mukai, S. Ohta, T. Mizukami, R. Sasaki, and K. Shin-ya
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Journal Title
J. Antibiot
Volume: 63
Pages: 139-141
NAID
Related Report
Peer Reviewed
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[Journal Article] A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells2010
Author(s)
T. Kunoh, T. Noda, K. Koseki, M. Sekigawa, M. Takagi, K. Shinya, N. Goshima, S. Iemura, T. Natsume, S. Wada, Y. Mukai, S. Ohta, R. Sasaki, and T. Mizukami
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Journal Title
Mol. Cancer Therap
Volume: 9
Pages: 2934-2942
Related Report
Peer Reviewed
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