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New natural compounds that inhibit development and hatching of echinoderm embryos.

Research Project

Project/Area Number 21510235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionNagahama Institute of Bio-Science and Technology

Principal Investigator

OHTA Shinji  長浜バイオ大学, バイオサイエンス学部, 教授 (60185270)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords天然物有機化学 / 生物活性物質 / 海綿 / ポリアセチレン / 胚発生 / ヒトデ / 発生阻害 / 孵化阻害
Research Abstract

New linear polyacetylene compounds designated petroacetylene and bromotheoynic acid have been isolated from the marine sponge Petrosia solida Hoshino 1981 and Theonella swinhoei, respectively, collected off the coast of Kagoshima Prefecture, Japan. The structures were elucidated on the basis of spectroscopic data and chemical means. We have evaluated the effects of the new polyacetylenes on development and hatching of echinoderm embryos.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (13 results)

  • [Journal Article] Bromotheoynic acid, a brominated acetylenic acid from the marine sponge Theonella swinhoei2012

    • Author(s)
      N.Aoki, K.Yamamoto, T. Ogawa, E.Ohta, T.Ikeuchi, K.Kamemura, S.Ikegami, S.Ohta
    • Journal Title

      Natural Product Research

      Volume: (印刷中) Issue: 2 Pages: 117-122

    • DOI

      10.1080/14786419.2012.660636

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABA metabolismpathway genes, UGA1 and GAD1, regulatereplicative lifespan in Saccharomycescerevisiae2011

    • Author(s)
      Y. Kamei, T. Tamura, R. Yoshida, S. Ohta, E. Fukusaki, Y. Mukai.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 407 Pages: 185-190

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bioactivejatrophane diterpenes from Euphorbia guyoniana2010

    • Author(s)
      M. F. Hegazy, A. E. H. Mohamed, N. Aoki, T. Ikeuchi, E. Ohta, and S. Ohta
    • Journal Title

      Phytochemistry

      Volume: 71 Pages: 249-253

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] JBIR-14, a highly oxygenated ergostane, from Isaria sp. NBRC 1043532010

    • Author(s)
      M. Takagi, J. Ueda, T. Kunoh, M. Sekigawa, S. Wada, Y. Mukai, S. Ohta, T. Mizukami, R. Sasaki, and K. Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 63 Pages: 139-141

    • NAID

      10030707998

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ComprehensiveScreening of Human Genes with InhibitoryEffects on Yeast Growth and Validation ofa Yeast Cell-Based System for ScreeningChemicals2010

    • Author(s)
      M. Sekigawa, T. Kunoh, S. Wada, Y. Mukai, K. Ohshima, S. Ohta, N. Goshima, R. Sasaki and T. Mizukami.
    • Journal Title

      J. Biomol. Screen

      Volume: 15 Pages: 368-378

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Saikachinoside A, a novel3-prenylated isoguanine glucoside fromseeds of Gleditsia japonica2010

    • Author(s)
      T. Kajimoto, N. Aoki, E. Ohta, Y. Kawai, and S. Ohta
    • Journal Title

      Tetrahedron Lett

      Volume: 51 Pages: 2099-2101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ashitabaol A, a new antioxidative sesquiterpenoid from seeds of Angelica keiskei2010

    • Author(s)
      N. Aoki and S. Ohta
    • Journal Title

      Tetrahedron Lett

      Volume: 51 Pages: 3449-3450

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells2010

    • Author(s)
      T. Kunoh, T. Noda, K. Koseki, M. Sekigawa, M. Takagi, K. Shinya, N. Goshima, S. Iemura, T. Natsume, S. Wada, Y. Mukai, S. Ohta, R. Sasaki, and T. Mizukami
    • Journal Title

      Mol. Cancer Therap

      Volume: 9 Pages: 2934-2942

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Locustoside A-A new purine alkaloidglucoside from seeds of Gleditsia japonica2010

    • Author(s)
      T. Kajimoto, N. Aoki, E. Ohta, and S. Ohta.
    • Journal Title

      Phytochemistry Lett

      Volume: 3 Pages: 198-200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxicity of3-O-(β-D-Glucopyranosyl) etioline, aSteroidal Alkaloid from Solanum diphyllum2009

    • Author(s)
      M. A. El-Sayed, A. E. H. Mohamed, M. K. Hassan, M. F. Hegazy, S. J. Hossain, M. G. Sheded, and S. Ohta.
    • Journal Title

      L. Z. Naturforsch. C

      Volume: 64 Pages: 644-649

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bromotheoynic acid, a brominatedacetylenic acid from the marine sponge Theonella swinhoei

    • Author(s)
      N. Aoki, K. Yamamoto, T. Ogawa, E. Ohta, T. Ikeuchi, K. Kamemura, S. Ikegami and S. Ohta
    • Journal Title

      Nat. Prod. Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] N-プレニル化プリンアルカロイド類縁体の合成と生理活性2011

    • Author(s)
      梶本将史、太田伸二
    • Organizer
      第55回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      筑波
    • Year and Date
      2011-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] ビサボラン型セスキテルペン、アシタバオールAの絶対配置とラジカル消去活性2011

    • Author(s)
      青木信和・太田伸二
    • Organizer
      第55回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] N-プレニル化プリンアルカロイド類縁体の合成と生理活性2011

    • Author(s)
      梶本将史・太田伸二
    • Organizer
      第55回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] サイカチマメゾウムシ(Bruchidiusdorsalis)幼虫から得られた新規デヒドロフェニルアラニン含有リピドの構造と生理活性2011

    • Author(s)
      廣瀬弥生、太田恵美、梶本将史、太田伸二
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] サイカチ(Gleditsiajaponica)種子由来の新規プリンアルカロイドの構造と活性2011

    • Author(s)
      梶本将史、青木信和、太田恵美、太田伸二
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] アシタバ種子由来の新規セスキテルペノイド類の構造と抗酸化作用2010

    • Author(s)
      青木信和・太田伸二
    • Organizer
      第54回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      山梨大学(山梨県)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] サイカチ(Gleditsia japonica)種子由来のアセチルコリンエステラーゼ活性化物質2010

    • Author(s)
      梶本将史・青木信和・太田恵美・河合靖・太田伸二
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡市・グランシップ(静岡県)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] アシタバ種子に含まれる新規生理活性セスキテルペノイド類2010

    • Author(s)
      青木信和、白井正明、太田伸二
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      東大阪
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 発芽種子の生理活性成分2009

    • Author(s)
      太田伸二
    • Organizer
      第53回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      奈良
    • Year and Date
      2009-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] アシタバ種子由来の新規生理活性物質2009

    • Author(s)
      青木信和、白井正明、太田伸二
    • Organizer
      第40回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] バクテリア由来の新規生理活性物質の構造とヒトデ胚発生過程に対する影響2009

    • Author(s)
      鬼塚明也、太田恵美、村上祐美、向由起夫、池上晋、太田伸二
    • Organizer
      第40回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] アシタバ種子由来の新規生理活性物質2009

    • Author(s)
      青木信和、白井正明、太田伸二
    • Organizer
      第40回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] バクテリア由来の新規生理活性物質の構造とヒトデ胚発生過程に対する影響2009

    • Author(s)
      鬼塚明也・太田恵美・村上祐美・向由起夫・池上晋・太田伸二
    • Organizer
      第40回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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