New natural compounds that inhibit development and hatching of echinoderm embryos.

• Project/Area Number: 21510235
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Nagahama Institute of Bio-Science and Technology
• Principal Investigator: OHTA Shinji 長浜バイオ大学, バイオサイエンス学部, 教授 (60185270)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 天然物有機化学 / 生物活性物質 / 海綿 / ポリアセチレン / 胚発生 / ヒトデ / 発生阻害 / 孵化阻害

Research Abstract

New linear polyacetylene compounds designated petroacetylene and bromotheoynic acid have been isolated from the marine sponge Petrosia solida Hoshino 1981 and Theonella swinhoei, respectively, collected off the coast of Kagoshima Prefecture, Japan. The structures were elucidated on the basis of spectroscopic data and chemical means. We have evaluated the effects of the new polyacetylenes on development and hatching of echinoderm embryos.

Research Products

• [Journal Article] Bromotheoynic acid, a brominated acetylenic acid from the marine sponge Theonella swinhoei (2012)
  • Author(s): N.Aoki, K.Yamamoto, T. Ogawa, E.Ohta, T.Ikeuchi, K.Kamemura, S.Ikegami, S.Ohta
  • Journal Title: Natural Product Research Volume: (印刷中) Issue: 2 Pages: 117-122
  • DOI: 10.1080/14786419.2012.660636
  • Peer Reviewed
• [Journal Article] GABA metabolismpathway genes, UGA1 and GAD1, regulatereplicative lifespan in Saccharomycescerevisiae (2011)
  • Author(s): Y. Kamei, T. Tamura, R. Yoshida, S. Ohta, E. Fukusaki, Y. Mukai.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 407 Pages: 185-190
  • Peer Reviewed
• [Journal Article] Bioactivejatrophane diterpenes from Euphorbia guyoniana (2010)
  • Author(s): M. F. Hegazy, A. E. H. Mohamed, N. Aoki, T. Ikeuchi, E. Ohta, and S. Ohta
  • Journal Title: Phytochemistry Volume: 71 Pages: 249-253
  • Peer Reviewed
• [Journal Article] JBIR-14, a highly oxygenated ergostane, from Isaria sp. NBRC 104353 (2010)
  • Author(s): M. Takagi, J. Ueda, T. Kunoh, M. Sekigawa, S. Wada, Y. Mukai, S. Ohta, T. Mizukami, R. Sasaki, and K. Shin-ya
  • Journal Title: J. Antibiot Volume: 63 Pages: 139-141
  • NAID: 10030707998
  • Peer Reviewed
• [Journal Article] ComprehensiveScreening of Human Genes with InhibitoryEffects on Yeast Growth and Validation ofa Yeast Cell-Based System for ScreeningChemicals (2010)
  • Author(s): M. Sekigawa, T. Kunoh, S. Wada, Y. Mukai, K. Ohshima, S. Ohta, N. Goshima, R. Sasaki and T. Mizukami.
  • Journal Title: J. Biomol. Screen Volume: 15 Pages: 368-378
  • Peer Reviewed
• [Journal Article] Saikachinoside A, a novel3-prenylated isoguanine glucoside fromseeds of Gleditsia japonica (2010)
  • Author(s): T. Kajimoto, N. Aoki, E. Ohta, Y. Kawai, and S. Ohta
  • Journal Title: Tetrahedron Lett Volume: 51 Pages: 2099-2101
  • Peer Reviewed
• [Journal Article] Ashitabaol A, a new antioxidative sesquiterpenoid from seeds of Angelica keiskei (2010)
  • Author(s): N. Aoki and S. Ohta
  • Journal Title: Tetrahedron Lett Volume: 51 Pages: 3449-3450
  • Peer Reviewed
• [Journal Article] A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells (2010)
  • Author(s): T. Kunoh, T. Noda, K. Koseki, M. Sekigawa, M. Takagi, K. Shinya, N. Goshima, S. Iemura, T. Natsume, S. Wada, Y. Mukai, S. Ohta, R. Sasaki, and T. Mizukami
  • Journal Title: Mol. Cancer Therap Volume: 9 Pages: 2934-2942
  • Peer Reviewed
• [Journal Article] Locustoside A-A new purine alkaloidglucoside from seeds of Gleditsia japonica (2010)
  • Author(s): T. Kajimoto, N. Aoki, E. Ohta, and S. Ohta.
  • Journal Title: Phytochemistry Lett Volume: 3 Pages: 198-200
  • Peer Reviewed
• [Journal Article] Cytotoxicity of3-O-(β-D-Glucopyranosyl) etioline, aSteroidal Alkaloid from Solanum diphyllum (2009)
  • Author(s): M. A. El-Sayed, A. E. H. Mohamed, M. K. Hassan, M. F. Hegazy, S. J. Hossain, M. G. Sheded, and S. Ohta.
  • Journal Title: L. Z. Naturforsch. C Volume: 64 Pages: 644-649
  • Peer Reviewed
• [Journal Article] Bromotheoynic acid, a brominatedacetylenic acid from the marine sponge Theonella swinhoei
  • Author(s): N. Aoki, K. Yamamoto, T. Ogawa, E. Ohta, T. Ikeuchi, K. Kamemura, S. Ikegami and S. Ohta
  • Journal Title: Nat. Prod. Res
  • Peer Reviewed
• [Presentation] N-プレニル化プリンアルカロイド類縁体の合成と生理活性 (2011)
  • Author(s): 梶本将史、太田伸二
  • Organizer: 第55回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 筑波
  • Year and Date: 2011-11-20
• [Presentation] ビサボラン型セスキテルペン、アシタバオールAの絶対配置とラジカル消去活性 (2011)
  • Author(s): 青木信和・太田伸二
  • Organizer: 第55回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 筑波大学(茨城県)
  • Year and Date: 2011-11-20
• [Presentation] N-プレニル化プリンアルカロイド類縁体の合成と生理活性 (2011)
  • Author(s): 梶本将史・太田伸二
  • Organizer: 第55回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 筑波大学(茨城県)
  • Year and Date: 2011-11-20
• [Presentation] サイカチマメゾウムシ(Bruchidiusdorsalis)幼虫から得られた新規デヒドロフェニルアラニン含有リピドの構造と生理活性 (2011)
  • Author(s): 廣瀬弥生、太田恵美、梶本将史、太田伸二
  • Organizer: 第53回天然有機化合物討論会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-27
• [Presentation] サイカチ(Gleditsiajaponica)種子由来の新規プリンアルカロイドの構造と活性 (2011)
  • Author(s): 梶本将史、青木信和、太田恵美、太田伸二
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-26
• [Presentation] アシタバ種子由来の新規セスキテルペノイド類の構造と抗酸化作用 (2010)
  • Author(s): 青木信和・太田伸二
  • Organizer: 第54回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 山梨大学(山梨県)
  • Year and Date: 2010-10-23
• [Presentation] サイカチ(Gleditsia japonica)種子由来のアセチルコリンエステラーゼ活性化物質 (2010)
  • Author(s): 梶本将史・青木信和・太田恵美・河合靖・太田伸二
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: 静岡市・グランシップ(静岡県)
  • Year and Date: 2010-09-30
• [Presentation] アシタバ種子に含まれる新規生理活性セスキテルペノイド類 (2010)
  • Author(s): 青木信和、白井正明、太田伸二
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 東大阪
  • Year and Date: 2010-03-28
• [Presentation] 発芽種子の生理活性成分 (2009)
  • Author(s): 太田伸二
  • Organizer: 第53回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 奈良
  • Year and Date: 2009-11-08
• [Presentation] アシタバ種子由来の新規生理活性物質 (2009)
  • Author(s): 青木信和、白井正明、太田伸二
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-11-07
• [Presentation] バクテリア由来の新規生理活性物質の構造とヒトデ胚発生過程に対する影響 (2009)
  • Author(s): 鬼塚明也、太田恵美、村上祐美、向由起夫、池上晋、太田伸二
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-11-07
• [Presentation] アシタバ種子由来の新規生理活性物質 (2009)
  • Author(s): 青木信和、白井正明、太田伸二
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜大学(岐阜県)
• [Presentation] バクテリア由来の新規生理活性物質の構造とヒトデ胚発生過程に対する影響 (2009)
  • Author(s): 鬼塚明也・太田恵美・村上祐美・向由起夫・池上晋・太田伸二
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜大学(岐阜県)