| Project/Area Number |
21530735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical psychology
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAAKI Shutaro 名古屋市立大学, 大学院・医学研究科, 研究員 (80315879)
MIMURA Masaru 慶応義塾大学, 医学部, 教授 (00190728)
古川 壽亮 名古屋市立大学, 大学院・医学研究科, 教授 (90275123)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Toshiaki 京都大学, 医学研究科, 教授 (90275123)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 行動学 / 脳と神経 / 行動療法 / 脳形態 / VBM / 強迫性障害 / 脳形態画像 / 高次脳機能 / 前頭葉 |
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| Research Abstract |
In this study, we examined the existence of regional structural abnormalities in both the gray matter(GM) and the white matter(WM) of patients with OCD at baseline using a voxel-based morphometry(VBM) approach in responders and non-responders to subsequent BT. In addition, we examined the abnormalities using neuropsychological approach. TheT1-weighted magnetic resonance imaging studies were performed before the completion of 12 weeks of BT. Relative to the responders, the non-responders exhibited significantly smaller GM volumes in the right ventromedial prefrontal cortex, the right orbitofrontal cortex(OFC), the right anterior cingulate cortex(ACC). In addition, relative to the responders, the non-responders exhibited significantly smaller WM volumes in the left cingulate bundle, bilateral cingulate bundles. Two groups exhibited the difference on the part of the attention/executive functions. These results suggest that brain structures in several areas including the OFC, ACC, and cingulate bundles are related to the lack of a response to BT in patients with OCD. The use of a VBM approach may be advantageous to understanding differences between responders and non-responders.
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