| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Neural mechanisms underlying extinction and/or reconsolidation of euphoric or aversive emotional memory were investigated using classical fear conditioning and conditioned place preference in rats. Results showed that (1) the extinction during the reconsolidation window could facilitate a generalization of the extinction between CS's, (2) NMDA receptor agonist could facilitate extinction of fear responses, (3) dopamine D1 and D2 receptors were involved in an acquisition and reinstatement of metamphetamine-induced CPP, respectively.
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