| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The role of hippocampal-prefrontal system, especially its glutamatergic NMDA receptors, in spatial working memory was investigated by behavioral pharmacological techniques using intracerebral administration of a NMDA receptor antagonist. It has been known from previous studies that the antagonist treated into the dorsal hippocampus causes marked deficits in radial maze behavior in rats. The present study revealed that the antagonist treated into the ventral hippocampus and the medial prefrontal cortex also caused deficits of these learned behaviors. Additionally, systemic administration of a partial agonist of the receptor exerted facilitative effect on spontaneous object place recognition performance. The results suggest that NMDA receptors in the hippocampal-prefrontal system play an important role in spatial working memory.
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