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Psychological and physiological studies on circadian rhythm in the memory system

Research Project

Project/Area Number 21530771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionSophia University

Principal Investigator

OKADA Takashi  上智大学, 総合人間科学部, 教授 (00242082)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords海馬 / 長期増強 / メラトニン / 一酸化窒素 / 記憶 / 概日リズム / 物体再認課題 / 概目リズム
Research Abstract

Hippocampal long-term potentiation(LTP), which is thought of as a candidate for the physiological basis of memory, is reportedly reduced in the presence of melatonin, whose pattern of secretion shows a circadian rhythm. In this study, I electrophysiologically examined the mechanisms of inhibition of hippocampal LTP by melatonin. The inhibitory effects of an inhibitor of NO synthase and melatonin were occluded by each other, and an NO donor disrupted the inhibition of LTP, which leads to the idea that the target of melatonin for LTP inhibition is the NO pathway.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (40 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (32 results) Book (1 results)

  • [Journal Article] Stratum oriens stimulation-evoked modulation of hippocampal long-term potentiation involves the activation of muscarinic acetylcholine receptors and the inhibition of Kv7/M potassium ion channels.2012

    • Author(s)
      Suzuki, E. & Okada, T.
    • Journal Title

      European Journal of Neuroscience

      Volume: 36 Issue: 1 Pages: 1984-1992

    • DOI

      10.1111/j.1460-9568.2012.08127.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields2011

    • Author(s)
      Suzuki, E., Sato, M., Takezawa, R., Suzuki, E., Sato, M., Takezawa, R., Usuki, T. & Okada, T
    • Journal Title

      Journal of Physiological Sciences

      Volume: 61 Issue: 5 Pages: 421-427

    • DOI

      10.1007/s12576-011-0159-6

    • NAID

      10029575839

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the nitric oxide cascade in melatonin-induced inhibition of long-term potentiation at hippocampal CA1 synapses2011

    • Author(s)
      Takahashi, Y. & Okada, T
    • Journal Title

      Neuroscience Research

      Volume: 69 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.neures.2010.09.004

    • NAID

      10028189836

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Group I metabotropic glutamate receptors are involved in TEA-induced long-term potentiation at mossy fiber-CA3 synapses in the rat hippocampus2010

    • Author(s)
      Suzuki, E. & Okada, T
    • Journal Title

      Brain Research

      Volume: 1313 Pages: 45-52

    • DOI

      10.1016/j.brainres.2009.11.059

    • NAID

      120005885320

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Group I metabotropic glutamate receptors are involved in TEA-induced long-term potentiation at mossy fiber-CA3 synapses in the rat hippocampus2010

    • Author(s)
      Suzuki, E., Okada, T.
    • Journal Title

      Brain Research 1313

      Pages: 45-52

    • NAID

      120005885320

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 海馬シナプス機能を下位領域間で比較する-非侵襲的測定研究の可能性-2009

    • Author(s)
      岡田隆
    • Journal Title

      基礎心理学研究

      Volume: 28 Pages: 17-22

    • URL

      http://ci.nii.ac.jp/naid/110007482448

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 海馬シナプス機能を下位領域間で比較する -非侵襲的測定研究の可能性-2009

    • Author(s)
      岡田隆
    • Journal Title

      基礎心理学研究 28

      Pages: 17-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] アセチルコリン受容体活性化による海馬長期増強促進における膜電位依存性Ca^<2+>チャネルの関与2011

    • Author(s)
      鈴木江津子・岡田隆
    • Organizer
      日本基礎心理学会第30回大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ラットの位置再認課題成績にみられる日内変動2011

    • Author(s)
      高橋良幸・澤幸祐・岡田隆
    • Organizer
      日本基礎心理学会第30回大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 海馬に作用するイチョウ葉特有成分テルペントリラクトンに関する研究2011

    • Author(s)
      佐藤麻希子・武澤遼太・鈴木江津子・岡田隆・臼杵豊展
    • Organizer
      第55回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      筑波
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海馬CA1長期増強の上昇層刺激誘導性促進における刺激強度依存性2011

    • Author(s)
      鈴木江津子・岡田隆
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ラットの物体再認課題成績にみられる日内変動2011

    • Author(s)
      高橋良幸・澤幸祐・岡田隆
    • Organizer
      日本動物心理学会第71回大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ラットの物体再認課題成績にみられる日内変動2011

    • Author(s)
      高橋良幸・澤幸祐・岡田隆
    • Organizer
      日本動物心理学会第71回大会(Animal2011)
    • Place of Presentation
      東京
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] アセチルコリン受容体活性化によるラット海馬CA1長期増強促進におけるKv7/Mカリウムイオンチャネルの関与2011

    • Author(s)
      鈴木江津子・岡田隆
    • Organizer
      日本動物心理学会第71回大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-08
    • Related Report
      2011 Final Research Report
  • [Presentation] アセチルコリン受容体活性化によるラット海馬CA1長期増強促進におけるKv7/Mカリウムイオンチャネルの関与2011

    • Author(s)
      鈴木江津子・岡田隆
    • Organizer
      日本動物心理学会第71回大会(Animal2011)
    • Place of Presentation
      東京
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Modulation of hippocampal long-term potentiation by activation of the muscarinic acetylcholine receptors involves the inhibition of Kv7/M potassium channels2011

    • Author(s)
      Suzuki, E. & Okada, T
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence(Italy)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Modulation of hippocampal long-term potentiation by activation of the muscarinic acetylcholine receptors involves the inhibition of Kv7/M potassium channels2011

    • Author(s)
      Suzuki, E., Okada, T.
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] メラトニンによる海馬長期増強減弱効果における一酸化窒素経路とPKA経路の相互作用2010

    • Author(s)
      高橋良幸・岡田隆
    • Organizer
      日本基礎心理学会第29回大会
    • Place of Presentation
      西宮
    • Year and Date
      2010-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] メラトニンによる海馬長期増強減弱効果における一酸化窒素経路とPKA経路の相互作用2010

    • Author(s)
      高橋良幸, 岡田隆
    • Organizer
      日本基礎心理学会第29回大会
    • Place of Presentation
      関西学院大学(兵庫県)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] イチョウ葉特有成分ビロバライドが海馬神経伝達および可塑性に与える影響2010

    • Author(s)
      鈴木江津子・佐藤麻希子・臼杵豊展・岡田隆
    • Organizer
      海馬と高次脳機能学会第19回大会
    • Place of Presentation
      金沢
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] The involvement of Group I mGluR in tetraethylammonium-induced long-term potentiation at hippocampal mossy fiber-CA3 synapses2010

    • Author(s)
      Suzuki, E. & Okada, T
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] The involvement of Group I mGluR in tetraethylammonium-induced long-term potentiation at hippocampal mossy fiber-CA3 synapses2010

    • Author(s)
      Suzuki, E., Okada, T.
    • Organizer
      第33回日本神経科学大会(Neuro2010)
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Melatonin inhibits hippocampal LTP via nitric oxide signaling pathway2010

    • Author(s)
      Takahashi, Y. & Okada, T
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Melatonin inhibits hippocampal LTP via nitric oxide signaling pathway.2010

    • Author(s)
      Takahashi, Y., Okada, T.
    • Organizer
      第33回日本神経科学大会(Neuro2010)
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] メラトニンはシナプス後部の一酸化窒素信号経路を介して海馬長期増強を減弱させる2010

    • Author(s)
      高橋良幸・岡田隆
    • Organizer
      日本動物心理学会第70回大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-29
    • Related Report
      2011 Final Research Report
  • [Presentation] イチョウ葉特有成分ビロバライドがラット海馬神経伝達に与える影響2010

    • Author(s)
      鈴木江津子・佐藤麻希子・臼杵豊展・岡田隆
    • Organizer
      日本動物心理学会第70回大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-29
    • Related Report
      2011 Final Research Report
  • [Presentation] イチョウ葉特有成分ビロバライドがラット海馬神経伝達に与える影響2010

    • Author(s)
      鈴木江津子, 佐藤麻希子, 臼杵豊展, 岡田隆
    • Organizer
      日本動物心理学会第70回大会
    • Place of Presentation
      帝京大学(東京都)
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] メラトニンはシナプス後部の一酸化窒素信号経路を介して海馬長期増強を減弱させる2010

    • Author(s)
      高橋良幸, 岡田隆
    • Organizer
      日本動物心理学会第70回大会
    • Place of Presentation
      帝京大学(東京都)
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] The characteristics of tetraethylammoniuminduced long-term potentiation at mossy fiber-CA3 synapses in the rat hippocampus2010

    • Author(s)
      Suzuki, E. & Okada, T
    • Organizer
      7th FENS forum of European neuroscience
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2010-07-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Melatonin inhibits long-term hippocampal potentiation via the nitric oxide signaling pathway2010

    • Author(s)
      Takahashi, Y. & Okada, T
    • Organizer
      7th FENS forum of European neuroscience
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2010-07-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Melatonin inhibits long-term hippocampal potentiation via the nitric oxide signaling pathway.2010

    • Author(s)
      Takahashi, Y., Okada, T.
    • Organizer
      7th FENS forum of European Neuroscience
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The characteristics of tetraethylammonium-induced long-term potentiation at mossy fiber-CA3 synapses in the rat hippocampus2010

    • Author(s)
      Suzuki, E., Okada.T.
    • Organizer
      7th FENS forum of European Neuroscience
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] メラトニンによる海馬長期増強の減弱効果は一酸化窒素信号経路を介する2009

    • Author(s)
      高橋良幸・岡田隆
    • Organizer
      日本基礎心理学会第28回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 海馬苔状線維-CA3シナプス長期増強誘導におけるシナプス後部の関与2009

    • Author(s)
      鈴木江津子・岡田隆
    • Organizer
      日本基礎心理学会第28回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット海馬CA3シナプス可塑性における代謝型グルタミン酸受容体の関与2009

    • Author(s)
      鈴木江津子・岡田隆
    • Organizer
      日本動物心理学会第69回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット海馬長期増強を減弱させるメラトニンの作用機序2009

    • Author(s)
      高橋良幸・岡田隆
    • Organizer
      日本動物心理学会第69回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Tetraethylammonium-induced long-term plasticity at hippocampal mossy fiber-CA3 synapses2009

    • Author(s)
      Suzuki, E. & Okada, T
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Melatonin attenuates long-term potentiation via inhibition of nitric oxide signaling pathway in rat hippocampus2009

    • Author(s)
      Takahashi, Y. & Okada, T
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Melatonin attenuates long-term potentiation via inhibition of nitric oxide signaling pathway in rat hippocampus2009

    • Author(s)
      Takahashi, Y., Okada, T.
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Book] 認知神経科学2012

    • Author(s)
      道又爾・岡田隆
    • Publisher
      放送大学教育振興会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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