| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Hippocampal long-term potentiation(LTP), which is thought of as a candidate for the physiological basis of memory, is reportedly reduced in the presence of melatonin, whose pattern of secretion shows a circadian rhythm. In this study, I electrophysiologically examined the mechanisms of inhibition of hippocampal LTP by melatonin. The inhibitory effects of an inhibitor of NO synthase and melatonin were occluded by each other, and an NO donor disrupted the inhibition of LTP, which leads to the idea that the target of melatonin for LTP inhibition is the NO pathway.
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