Neuronal circuit of eyeblink conditioning in mice

• Project/Area Number: 21530781
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: University of Tsukuba
• Principal Investigator: SAKAMOTO Toshiriou 筑波大学, 教育イニシアティブ機構, 准教授 (40321765)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 瞬目反射条件づけ / 小脳 / 扁桃体 / マウス / 瞬目反射 / 社会行動 / 海馬 / 行動解析 / 赤核

Research Abstract

Amygdala is critical for eyeblink conditioning in mice when the salient conditioned stimulus (CS) was used. Furthermore, we conducted the tone frequency discrimination task using deep cerebellar nuclei (DCN) lesioned mice. DCN lesioned mice could not acquire the discrimination task, and the results indicate that cerebellum is critically involved in the complicated cognitive task in eyeblink conditioning.

Research Products

• [Journal Article] The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease (2010)
  • Author(s): H. J. Lee, J. K. Lee, H.Lee, J. Shin, , J. E. Carter, T. Sakamoto, H.K. Jin, J.Bae
  • Journal Title: Neuroscience Letters Volume: 481 Pages: 30-35
• [Journal Article] Amygdala, deep cerebellar nuclei and red nucleus contribute to delay eyeblink conditioning in C57BL/6mice (2010)
  • Author(s): T. Sakamoto & S. Endo
  • Journal Title: European Journal of Neuroscience Volume: 32 Pages: 1537-1551
• [Journal Article] Amygdala, deep cerebellar nuclei and red nucleus contribute to delay eyeblink conditioning in C57BL/6 mice (2010)
  • Author(s): T.Sakamoto, S.Endo
  • Journal Title: European Journal of Neuroscience Volume: 32 Pages: 1537-1551
  • Peer Reviewed
• [Journal Article] Dual involvement of G-substrate in motor learning revealed by gene deletion (2009)
  • Author(s): S. Endo, F. Shutoh, T.L. Dinh, T. Okamoto, T. Ikeda, M. Suzuki, S. Kawahara, D.Yanagihara, Y. Sato, K. Yamada, T. Sakamoto, Y.Kirino, N.A. Hartell, K. Yamaguchi, S. Itohara, A.C. Nairn, P. Greemgard, S. Nagao, & M. Ito
  • Journal Title: Proceedings of the National Academic Sciences of the U.S.A. Volume: 106 Pages: 3525-3530
  • NAID: 120006399303
• [Journal Article] 小脳核のGABAA受容体 (2009)
  • Author(s): 坂本敏郎, 遠藤昌吾
  • Journal Title: 生体の科学 Volume: 60 Pages: 380-381
• [Journal Article] 小脳核のGABA_A受容体 (2009)
  • Author(s): 坂本敏郎・遠藤昌吾
  • Journal Title: 生体の科学 60 Pages: 380-381
• [Presentation] マウスの社会的認知に果たすオキシトシン受容体の役割 (2011)
  • Author(s): 坂本敏郎
  • Organizer: 「性と生殖」公開シンポジウム
  • Place of Presentation: 早稲田大学井深ホール(東京都)(招待講演)
  • Year and Date: 2011-12-04
• [Presentation] Impairment of socio-emotional behavior and memory function in Draxin (Dorsal repulsive axon guidance protein) knockout mice (2011)
  • Author(s): Sakamoto, T., Shinmyo, Y., Tanaka, H., & Ogawa, S.
  • Organizer: 39^<th> Annual meeting of Society for Neuroscience
  • Place of Presentation: Washington D.C
  • Year and Date: 2011-11-14
• [Presentation] Impairment of socio-emotional behavior and memory function in Draxin (Dorsal repulsive axon guidance protein) knockout mice (2011)
  • Author(s): 坂本敏郎
  • Organizer: 39th Annual meeting of Society for Neuroscience
  • Place of Presentation: ワシントンDC国際会議場(米国)
  • Year and Date: 2011-11-14
• [Presentation] The effect of brain impairment on socio-emotional behavior in mice (2011)
  • Author(s): 坂本敏郎
  • Organizer: First Asia-Pacific Conference on Integrative Behavioral Science
  • Place of Presentation: 陜西師範大学(中国)(招待講演)
  • Year and Date: 2011-07-26
• [Presentation] Impairment of socio-emotional 6ehavior and memory function in Draxin (Dorsal repulsive axon guidance protein) knockout mice. (2010)
  • Author(s): T.Sakamoto, Y.Shinmyo, H., 他2名
  • Organizer: 33th Annual meeting of Japan Neuroscience Society
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-04
• [Presentation] Role of oxytocin receptor in the regulation of social recognition in mice. (2010)
  • Author(s): N.Yamaguchi, T.Sakamoto, 他4名
  • Organizer: 33th Annual meeting of Japan Neuroscience Society
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-04
• [Presentation] 社会的認知及び空間認知機能におけるオキシトシン受容体の役割 (2010)
  • Author(s): 佐越祥子・坂本敏郎・小川園子
  • Organizer: 日本動物心理学会第70回大会
  • Place of Presentation: 帝京大学(人王子)
  • Year and Date: 2010-08-29
• [Presentation] Impairment of socio-emotional behavior and memory function in Draxin (Dorsal repulsive axon guidance protein) knockout mice (2010)
  • Author(s): T. Sakamoto, Y. Shinmyo, H. Tanaka, & S. Ogawa
  • Organizer: 33^<th> Annual meeting of Japan Neuroscience Society
  • Place of Presentation: Kobe
• [Presentation] 社会的認知及び空間認知機能におけるオキシトシン受容体の役割 (2010)
  • Author(s): 佐越祥子, 坂本敏郎, 小川園子
  • Organizer: 日本動物心理学会、第70回大会
  • Place of Presentation: 帝京大学(東京都)
• [Presentation] 扁桃体はマウス瞬目反射条件づけに重要な役割を持つ (2009)
  • Author(s): 坂本敏郎・小川園子・遠藤昌吾
  • Organizer: 日本動物心理学会第69回大会
  • Place of Presentation: 岐阜大学
  • Year and Date: 2009-09-27
• [Presentation] 思春期のステロイドホルモン環境が情動・社会行動に及ぼす影響 (2009)
  • Author(s): 柏村実生・津田夢芽子・K.E.Hood・C.L.Sisk・坂本敏郎・小川園子
  • Organizer: 日本動物心理学会第69回大会
  • Place of Presentation: 岐阜大学
  • Year and Date: 2009-09-27
• [Presentation] Lateral Amygdala plays important roles in acquisition and retention of delay eyeblink conditioning in mice (2009)
  • Author(s): 坂本敏郎, 小川園子, 遠藤昌吾
  • Organizer: 31th Annual meeting of Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] 扁桃体はマウス瞬目反射条件づけに重要な役割を持つ日本動物心理学会 (2009)
  • Author(s): 坂本敏郎, 小川園子, 遠藤昌吾
  • Organizer: 第69回大会
  • Place of Presentation: 岐阜大学(岐阜県)
• [Presentation] Lateral Amygdala plays important roles in acquisition and retention of delay eyeblink conditioning in mice (2009)
  • Author(s): T. Sakamoto, S. Ogawa & S. Endo
  • Organizer: 31^<th> Annual meeting of Japan Neuroscience Society
• [Remarks]
  • URL: http://www.kansei.tsukuba.ac.jp/~ogawalab/?category=11
• [Remarks]
  • URL: http://www.kansei.tsukuba.ac.jp/~ogawalab/
• [Remarks]
  • URL: http://www.kansei.tsukuba.ac.jp/~ogawalab/?category=11
• [Remarks]
  • URL: http://www.kansei.tsukuba.ac.jp/~ogawalab/?category=11