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Application of the brain functional analysis of autism spectrum disorders in order to establish an efficient medical and educational support system

Research Project

Project/Area Number 21531035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Special needs education
Research InstitutionBunkyo University

Principal Investigator

NARITA Naoko  文教大学, 教育学部, 教授 (40306189)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsセロトニン / 自閉症スペクトラム障害 / 図形課題 / 前頭前野 / 作業記憶 / スイッチングタスク / 発達障害 / 実行機能 / 脳血流
Research Abstract

We first examined prefrontal hemodynamic change according to reciprocal disposition of working memory(WM) and non-WM tasks of geometrical figures using near-infrared spectroscopy to compare high-functioning ASD subjects with controls. An evoked cerebral blood oxygenation(CBO) change was instantly observed in response to the task switch in the controls but not in ASD subjects, although the task performance rates were almost equivalent. Secondary, we measured CBO changes during facial expressions as stimuli in the same switching task. In ASD patients, no relevance between the task performance rate and the CBO change, which was shown in the controls.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (51 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 4 results) Presentation (9 results) Book (18 results) Remarks (10 results)

  • [Journal Article] Impaired prefrontal cortical response by switching stimuli in autism spectrum disorders2012

    • Author(s)
      Narita N, Saotome S, Higuchi H, Narita M, Tazoe M, Sakatani K.
    • Journal Title

      Journal of Pediatric Neurology

      Volume: 10 Pages: 1-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prefrontal cortical hemodynamic change due to facial expression switching task2012

    • Author(s)
      Higuchi H, Narita M, Sakatani K, Narita N
    • Journal Title

      Shonan Journal

      Volume: 3 Pages: 41-55

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Impaired prefrontal cortical response by switching stimuli in autism spectrum disorders2012

    • Author(s)
      Narita N, Saotome s, Higuchi H, Narita M, Tazoe M, Sakatani K
    • Journal Title

      Journal of Pediatric Neurology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] じゃれつき遊びによる前頭葉抑制機能の変化2011

    • Author(s)
      成田奈緒子、原田ゆかり、樋口大樹、田副真美、成田正明
    • Journal Title

      文教大学教育学部紀要

      Volume: 45 Pages: 81-89

    • NAID

      110009606563

    • Related Report
      2011 Final Research Report
  • [Journal Article] リズム遊びを中核とする介入による幼児の生活習慣改善と脳機能発達への有用性の検討2011

    • Author(s)
      成田奈緒子、田副真美
    • Journal Title

      日本小児科学会雑誌

      Volume: 114(12) Pages: 1882-1891

    • NAID

      10027695725

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 役割演技の脳科学的評価と学級活動への応用性の検討2010

    • Author(s)
      成田奈緒子・熊倉悠佳・田副真美・成田正明・酒谷薫
    • Journal Title

      文教大学教育学部紀要

      Volume: 44 Pages: 25-23

    • NAID

      110009606230

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] ADHDの臨床症状と脳の実行機能-モノアミン神経系との関連について-2010

    • Author(s)
      成田奈緒子
    • Journal Title

      現代のエスプリ

      Volume: 513 Pages: 70-77

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunohistochemical localization of manserin, a novel neuropeptide derived from secretogranin II, in rat adrenal gland and its upregulation by physical stress.2010

    • Author(s)
      Kamada N, Tano K, Oyabu A, Imura Y, Narita N, Tashiro Y, Uchida A, Komada Y, Narita M.
    • Journal Title

      International Journal of Peptide Research and Therapeutics

      Volume: 16 Pages: 55-61

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manserin, a secretogranin II-derived peptide, distributes in the rat endocrine pancreas colocalized with islet-cell specific manner.2010

    • Author(s)
      Tano K, Oyabu A, Tashiro Y, Kamada N, Narita N, Nasu F, Narita M
    • Journal Title

      Histochemistry and Cell Biology.

      Volume: 134 Pages: 53-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonexploratory Movement and Behavioral Alterations in a Thalidomide or Valproic Acid-induced Autism Model Rat2010

    • Author(s)
      Narita, M., Oyabu, A., Imura Y., Kamada, N., Yokoyama, T., Tano, K., Uchida, A., Narita, N.
    • Journal Title

      Neuroscience Res. 66

      Pages: 2-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADHDの臨床症状と脳の実行機能-モノアミン神経系との関連について-2010

    • Author(s)
      成田奈緒子
    • Journal Title

      現代のエスプリ 513

      Pages: 70-77

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 役割演技の脳科学・生理的評価とその有用性の検討2009

    • Author(s)
      熊倉悠佳、成田奈緒子
    • Journal Title

      教育研究ジャーナル

      Volume: 2(2) Pages: 23-24

    • Related Report
      2011 Final Research Report
  • [Journal Article] 特別な支援を必要とする児童への実践的支援の試み2009

    • Author(s)
      永田友美, 成田奈緒子
    • Journal Title

      教育研究ジャーナル 2

      Pages: 19-20

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 役割演技の脳科学・生理的評価とその有用性の検討2009

    • Author(s)
      熊倉悠佳, 成田奈緒子
    • Journal Title

      教育研究ジャーナル 2

      Pages: 23-24

    • Related Report
      2009 Annual Research Report
  • [Presentation] 自閉症スペクトラムにおけるタスクスイッチングへの呼応の遅延-近赤外線酸素モニターを用いた検討-2011

    • Author(s)
      成田奈緒子、田副真美、成田正明
    • Organizer
      第29回日本小児心身医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 自閉症の動物モデル2010

    • Author(s)
      成田正明、大薮明子、太城康良、成田奈緒子
    • Organizer
      第15回認知神経科学会学術集会
    • Place of Presentation
      松江
    • Related Report
      2011 Final Research Report
  • [Presentation] Pediatric developmental disorder, autism, caused by perturbation of serotonergic neuronal development induced by embryonic thalidomide exposure2010

    • Author(s)
      Narita M, Oyabu A, Tashiro Y, Narita N.
    • Organizer
      Neuro Talk
    • Place of Presentation
      Singapore
    • Related Report
      2011 Final Research Report
  • [Presentation] Manserin, a novel secretogranin II-derived peptide, distributes in the rat endocrine pancreas2010

    • Author(s)
      Kaori Tano, Akiko Oyabu, Yasura Tashiro, Naoki Kamada, Fumihiro Nasu, Masaaki Narita
    • Organizer
      The 39th Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired prefrontal cortical response by switching stimuli in autism spectrum disorders assessed by near-infrared spectroscopy.2010

    • Author(s)
      Masaaki Narita, Akiko Oyabu, Yasura Tashiro, Naoko Narita
    • Organizer
      Neuro Talk 2010
    • Place of Presentation
      Singapore
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自閉症の動物モデル2010

    • Author(s)
      成田正明、大薮明子、太城康良、成田奈緒子
    • Organizer
      第15回 認知神経科学会学術集会
    • Place of Presentation
      松江
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired prefrontal cortical response by switching stimuli in autism spectrum disorders assessed by near-infrared spectroscopy2009

    • Author(s)
      Saotome A, Tazoe M, Narita M, Sakatani S, Narita N
    • Organizer
      International meeting for autism research
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-05-07
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 脳血流動態からみた発達障害-神経化学的アプローチに生かせるか-2009

    • Author(s)
      成田奈緒子、五月女顕之、樋口大樹、熊倉悠佳
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Immunohistochemical localization of manserin, a novel neuropeptide derived from secretogranin II, in the rat adrenal glands ; relevance to stress response mechanism2009

    • Author(s)
      Kamada, K, Tano, K, Imura, Y, Oyabu, A, Yokoyaka, T, Narita, N, Tashiro, Y, Uchida, A, Narita, N
    • Organizer
      The 38th Society for Neuroscience Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Book] Obsessive Eating in The Handbook of Behavior, Diet and Nutrition.2012

    • Author(s)
      Naoko Narita, Mami Tazoe, and Masaaki Narita
    • Publisher
      Springer(In press)
    • Related Report
      2011 Final Research Report
  • [Book] 自閉症スペクトラムの前頭葉機能、「NIRSの基礎と臨床」2012

    • Author(s)
      成田奈緒子、酒谷薫他編集
    • Publisher
      新興医学出版社
    • Related Report
      2011 Final Research Report
  • [Book] 自閉症スペクトラムの前頭葉機能「NIRSの基礎と臨床」2012

    • Author(s)
      成田奈緒子
    • Total Pages
      278
    • Publisher
      新興医学出版社
    • Related Report
      2011 Annual Research Report
  • [Book] 障害に対応する絵本-障害・病気を理解するための絵本、絵本の事典2011

    • Author(s)
      成田奈緒子、中川素子, 吉田新一, 石井光恵, 佐藤博一
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] スライド資料及び指導の手引:「脳と心の発達メカニズム」2011

    • Author(s)
      成田奈緒子
    • Publisher
      東京都教育委員会
    • Related Report
      2011 Final Research Report
  • [Book] Hyperkalemia and hyperdopaminemia along with psychological modification induced by an obsessive eating of banana in an anorexia nervosa adolescent2011

    • Author(s)
      Naoko Narita, Mami Tazoe, and Masaaki Narita
    • Total Pages
      316
    • Publisher
      Nova Science
    • Related Report
      2011 Final Research Report
  • [Book] Hyperkalemia and hyperdopaminemia along with psychological modification induced by an obsessive eating of banana in an anorexia nervosa adolescent. in "Bananas : Nutrition, Diseases and Trade Issues"2011

    • Author(s)
      Naoko Narita, Mami Tazoe, Masaaki Narita.(分担執筆)
    • Total Pages
      316
    • Publisher
      Nova Science
    • Related Report
      2010 Annual Research Report
  • [Book] 早寝早起き朝ごはん2010

    • Author(s)
      成田奈緒子, 他
    • Total Pages
      9
    • Publisher
      国立青少年教育振興機構
    • Related Report
      2011 Final Research Report
  • [Book] 脳の鍛え方育て方2010

    • Author(s)
      成田奈緒子
    • Publisher
      すばる舎
    • Related Report
      2011 Final Research Report
  • [Book] くるくる変わる「育児の常識」2010

    • Author(s)
      成田奈緒子
    • Publisher
      小学館
    • Related Report
      2011 Final Research Report
  • [Book] できることから、始めてみよう!2010

    • Author(s)
      成田奈緒子, 他
    • Total Pages
      3
    • Publisher
      文部科学省全国協議会
    • Related Report
      2011 Final Research Report
  • [Book] 赤ちゃんの脳とこころを育てる親子レッスン2010

    • Author(s)
      成田奈緒子
    • Total Pages
      3
    • Publisher
      ブティック社
    • Related Report
      2011 Final Research Report
  • [Book] 早寝早起き朝ごはんガイド2010

    • Author(s)
      早寝早起き朝ごはん全国協議会(分担執筆)
    • Total Pages
      19
    • Publisher
      早寝早起き朝ごはん全国協議会事務局
    • Related Report
      2010 Annual Research Report
  • [Book] 赤ちゃんの脳とこころを育てる親子レッスン2010

    • Author(s)
      成田奈緒子(監修)
    • Total Pages
      96
    • Publisher
      ブティック社
    • Related Report
      2009 Annual Research Report
  • [Book] くるくる変わる「育児の常識」2010

    • Author(s)
      小学館編(分担執筆)
    • Total Pages
      160
    • Publisher
      小学館
    • Related Report
      2009 Annual Research Report
  • [Book] 小さいお子さんを育てている保護者のみなさんへ乳幼児期を大切に~心と体の基礎を育てるとき~2009

    • Author(s)
      成田奈緒子
    • Total Pages
      11
    • Publisher
      東京都教育委員会
    • Related Report
      2011 Final Research Report
  • [Book] 心療内科ハンドブック症例に学ぶ用語集2009

    • Author(s)
      成田奈緒子
    • Total Pages
      11
    • Publisher
      マイライフ社
    • Related Report
      2011 Final Research Report
  • [Book] 朝ごはん、どう食べる朝ごはんと脳の働き「食材の寺子屋-「食」から日本を考える2009

    • Author(s)
      成田奈緒子
    • Publisher
      NPO法人良い食材を伝える会
    • Related Report
      2011 Final Research Report
  • [Remarks] 研究代表者HP

    • URL

      http://www.geocities.jp/kosodatekagaku/

    • Related Report
      2011 Final Research Report
  • [Remarks] 東京都教育委員会「乳幼児からの子供の教育支援プロジェクトHP」(資料等作成)

    • URL

      http://www.nyuyoji-kyoiku-tokyo.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks] 研究代表者HP

    • URL

      http://www.geocities.jp/kosodatekagaku/

    • Related Report
      2011 Annual Research Report
  • [Remarks] 東京都教育委員会「乳幼児からの子供の教育支援プロジェクトHP」(資料等作成)

    • URL

      http://www.nyuyoji-kyoiku-tokyo.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks] 成田奈緒子HP

    • URL

      http://www.geocities.jp/kosodatekagaku/

    • Related Report
      2010 Annual Research Report
  • [Remarks] リズム遊びで早起き元気脳のHP

    • URL

      http://genkinou.net/

    • Related Report
      2010 Annual Research Report
  • [Remarks] 東京都教育委員会 乳幼児期からの子供教育支援プロジェクト

    • URL

      http://www.nyuyoji-kyoiku-tokyo.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks] 成田奈緒子HP

    • URL

      http://www.geocities.jp/kosodatekagaku/

    • Related Report
      2009 Annual Research Report
  • [Remarks] リズム遊びで早起き元気脳のHP

    • URL

      http://genkinou.net/

    • Related Report
      2009 Annual Research Report
  • [Remarks] 東京都教育委員会 乳幼児期からの子供教育支援プロジェクト

    • URL

      http://www.nyuyoji-kyoiku-tokyo.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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