Application of the brain functional analysis of autism spectrum disorders in order to establish an efficient medical and educational support system
| Project/Area Number |
21531035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Special needs education
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| Research Institution | Bunkyo University |
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Principal Investigator |
NARITA Naoko 文教大学, 教育学部, 教授 (40306189)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セロトニン / 自閉症スペクトラム障害 / 図形課題 / 前頭前野 / 作業記憶 / スイッチングタスク / 発達障害 / 実行機能 / 脳血流 |
|---|
| Research Abstract |
We first examined prefrontal hemodynamic change according to reciprocal disposition of working memory(WM) and non-WM tasks of geometrical figures using near-infrared spectroscopy to compare high-functioning ASD subjects with controls. An evoked cerebral blood oxygenation(CBO) change was instantly observed in response to the task switch in the controls but not in ASD subjects, although the task performance rates were almost equivalent. Secondary, we measured CBO changes during facial expressions as stimuli in the same switching task. In ASD patients, no relevance between the task performance rate and the CBO change, which was shown in the controls.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Immunohistochemical localization of manserin, a novel neuropeptide derived from secretogranin II, in rat adrenal gland and its upregulation by physical stress.2010
Author(s)
Kamada N, Tano K, Oyabu A, Imura Y, Narita N, Tashiro Y, Uchida A, Komada Y, Narita M.
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Journal Title
International Journal of Peptide Research and Therapeutics
Volume: 16
Pages: 55-61
Related Report
Peer Reviewed
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[Journal Article] Nonexploratory Movement and Behavioral Alterations in a Thalidomide or Valproic Acid-induced Autism Model Rat2010
Author(s)
Narita, M., Oyabu, A., Imura Y., Kamada, N., Yokoyama, T., Tano, K., Uchida, A., Narita, N.
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Journal Title
Neuroscience Res. 66
Pages: 2-6
Related Report
Peer Reviewed
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[Presentation] Immunohistochemical localization of manserin, a novel neuropeptide derived from secretogranin II, in the rat adrenal glands ; relevance to stress response mechanism2009
Author(s)
Kamada, K, Tano, K, Imura, Y, Oyabu, A, Yokoyaka, T, Narita, N, Tashiro, Y, Uchida, A, Narita, N
Organizer
The 38th Society for Neuroscience Annual Meeting
Place of Presentation
Chicago, USA
Related Report
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