Computational Science Study of Similarities and Differences between bacterial Ice-Nucleating Protein and Insect Anti-Freeze Protein
| Project/Area Number |
21540423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
NADA Hiroki 独立行政法人産業技術総合研究所, 環境管理技術研究部門, 主任研究員 (90357682)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Yoshinori 北海道大学, 低温科学研究所, 教授 (20113623)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 結晶成長 / 計算物理 / 表面・界面 / 機能性分子 / 分子シミュレーション / 氷核タンパク質 / 不凍タンパク質 |
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| Research Abstract |
In this project, similarities and differences between bacterial ice-nucleating protein(INP) and insect antifreeze protein(AFP) were studied using both computer simulation and ice crystal growth experiment. The results suggested that as a similarity, both INP and AFP are the proteins that significantly alter the anisotropy in ice crystal growth rate. The results also suggested that as a difference, INP binds selectively to ice basal planes, whereas AFP binds to both ice basal and prismatic planes. In conclusion, both INP and AFP are ice-binding proteins. However, the structure of INP is thought to be different from the structure of AFP.
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Report
(4 results)
Research Products
(35 results)
