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Computational Science Study of Similarities and Differences between bacterial Ice-Nucleating Protein and Insect Anti-Freeze Protein

Research Project

Project/Area Number 21540423
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics/Chemical physics
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

NADA Hiroki  独立行政法人産業技術総合研究所, 環境管理技術研究部門, 主任研究員 (90357682)

Co-Investigator(Renkei-kenkyūsha) FURUKAWA Yoshinori  北海道大学, 低温科学研究所, 教授 (20113623)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords結晶成長 / 計算物理 / 表面・界面 / 機能性分子 / 分子シミュレーション / 氷核タンパク質 / 不凍タンパク質
Research Abstract

In this project, similarities and differences between bacterial ice-nucleating protein(INP) and insect antifreeze protein(AFP) were studied using both computer simulation and ice crystal growth experiment. The results suggested that as a similarity, both INP and AFP are the proteins that significantly alter the anisotropy in ice crystal growth rate. The results also suggested that as a difference, INP binds selectively to ice basal planes, whereas AFP binds to both ice basal and prismatic planes. In conclusion, both INP and AFP are ice-binding proteins. However, the structure of INP is thought to be different from the structure of AFP.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (25 results)

  • [Journal Article] Antifreeze proteins : Computer simulation studies on the mechanism of ice growth inhibition2012

    • Author(s)
      灘浩樹,古川義純
    • Journal Title

      Polymer Journal

      Volume: (印刷中) Issue: 7 Pages: 690-698

    • DOI

      10.1038/pj.2012.13

    • NAID

      10030772399

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition at the ice prismatic plane induced by a spruce budworm antifreeze protein : a molecular dynamics simulation study2011

    • Author(s)
      灘浩樹,古川義純
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: Vol.13 Issue: 44 Pages: 19936-19942

    • DOI

      10.1039/c1cp21929d

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 不凍タンパク質による氷の成長抑制2011

    • Author(s)
      灘浩樹
    • Journal Title

      理論と計算科学研究,冷凍

      Volume: Vol.86 Pages: 545-550

    • Related Report
      2011 Final Research Report
  • [Journal Article] Analysis of ice crystal growth shape under high pressure using molecular dynamics simulation2011

    • Author(s)
      灘浩樹
    • Journal Title

      Crystal Growth & Design

      Volume: Vol.11 Issue: 7 Pages: 3130-3136

    • DOI

      10.1021/cg2003904

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A challenge to observe ice growth shape in molecular dynamics simulation2011

    • Author(s)
      灘浩樹
    • Journal Title

      Physics and Chemistry of Ice

      Volume: 2010 Pages: 293-298

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth mechanism of a hexagonal bipyramidal ice crystal in the presence of winter flounder antifreeze proteins2011

    • Author(s)
      灘浩樹,古川義純
    • Journal Title

      Physics and Chemistry of Ice

      Volume: 2010 Pages: 429-436

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant alternations in anisotropic ice growth rate induced by ice nucleation-active bacteria Xanthomonas Campestris2011

    • Author(s)
      灘浩樹,サルバドール・ゼペダ,三浦均,古川義純
    • Journal Title

      Chemical Physics Letters

      Volume: Vol.498 Issue: 1-3 Pages: 101-106

    • DOI

      10.1016/j.cplett.2010.08.062

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth mechanism of a hexagonal bipyramidal ice crystal in the presence of winter flounder antifreeze proteins2011

    • Author(s)
      灘浩樹、古川義純
    • Journal Title

      Physics and Chemistry of Ice 2010

      Pages: 429-436

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A challenge to observe ice growth shape in molecular dynamics simulation2011

    • Author(s)
      灘浩樹
    • Journal Title

      Physics and Chemistry of Ice 2010

      Pages: 293-298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant alternations in anisotropic ice growth rate induced by ice nucleation-active bacteria Xanthomonas Campestris2010

    • Author(s)
      灘浩樹、サルバドール・ゼペダ、三浦均、古川義純
    • Journal Title

      Chemical Physics Letters

      Volume: 498 Pages: 101-106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ice Crystal Growth Controlled by Antifreeze Proteins2011

    • Author(s)
      灘浩樹
    • Organizer
      NEPTIS-20
    • Place of Presentation
      大津プリンスホテル(滋賀)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Ice Crystal Growth Controlled by Antifreeze Proteins2011

    • Author(s)
      灘浩樹
    • Organizer
      NEPTIS-20
    • Place of Presentation
      大津プリンスホテル(滋賀)(招待講演)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 不凍タンパク質と氷核タンパク質共存下での氷の結晶成長2011

    • Author(s)
      灘浩樹, Salvador Zepeda,三浦均,古川義純
    • Organizer
      第41回結晶成長国内会議
    • Place of Presentation
      つくば国際会議場(茨城)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 不凍タンパク質の氷結晶界面吸着構造と分子レベル成長制御機構2011

    • Author(s)
      灘浩樹、古川義純
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Significant alternations in anisotropic ice growth rate induced by bacterial ice-nucleating proteins2011

    • Author(s)
      灘浩樹
    • Organizer
      1st International Ice-Binding Protein Conference
    • Place of Presentation
      キングストン大学(カナダ)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Significant alternations in anisotropic ice growth rate induced by bacterial ice-nucleating proteins2011

    • Author(s)
      灘浩樹
    • Organizer
      1st International Ice-Binding Protein Conference
    • Place of Presentation
      キングストン大学(カナダ)(招待講演)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Studies on mechanism of ice growth inhibition by antifreeze proteins2011

    • Author(s)
      灘浩樹
    • Organizer
      The 5th Asian Conference on Crystal Growth and Crystal Technology
    • Place of Presentation
      パンパシフィックシンガポールホテル(シンガポール)
    • Year and Date
      2011-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Studies on mechnanism of ice growth inhibition by antifreeze proteins2011

    • Author(s)
      灘浩樹
    • Organizer
      The 5th Asian Conference on Crystal Growth and Crystal Technology
    • Place of Presentation
      パンパシフィックシンガポールホテル(シンガポール)(招待講演)
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高圧下における氷結晶成長の分子動力学シミュレーション2010

    • Author(s)
      灘浩樹
    • Organizer
      日本物理学会2010年秋季大会
    • Place of Presentation
      大阪府立大学(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Growth shape of nanoscale hexagonal ice crystal : a molecular dynamics study2010

    • Author(s)
      灘浩樹
    • Organizer
      12^<th> International Conference on the Physics and Chemistry of Ice
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-09-10
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Anisotropic growth rate of ice in the presence of ice nucleation-active bacteria2010

    • Author(s)
      灘浩樹,サルバドール・ゼペダ,三浦均,古川義純
    • Organizer
      12th International Conference on the Physics and Chemistry of Ice
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Anisotropic growth rate of ice in the presence of ice nucleation-active bacteria2010

    • Author(s)
      灘浩樹、サルバドール・ゼペダ、三浦均、古川義純
    • Organizer
      12^<th> International Conference on the Physics and Chemistry of Ice
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Growth inhibition mechanism of ice by antifreeze protein : a molecular dynamics study2010

    • Author(s)
      灘浩樹,古川義純
    • Organizer
      12^<th> International Conference on the Physics and Chemistry of Ice
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-09-07
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Growth mechanism of tetrahydrofuran clathrate hydrate2010

    • Author(s)
      灘浩樹
    • Organizer
      12^<th> International Conference on the Physics and Chemistry of Ice
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2010-09-06
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Ice growth shape analyzed by molecular dynamics simulation2010

    • Author(s)
      灘浩樹
    • Organizer
      16^<th> International Conference on Crystal Growth
    • Place of Presentation
      北京国際コンベンションセンター(北京)
    • Year and Date
      2010-08-10
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 過冷却水中で成長する氷結晶の形態における結晶化潜熱の影響2010

    • Author(s)
      三浦均,灘浩樹,塚本勝男
    • Organizer
      日本地球惑星科学連合2010年大会
    • Place of Presentation
      幕張メッセ国際会議場(千葉)
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Growth mechanism of tetrahydrofuran clathrate hydrate : a molecular dynamics study2010

    • Author(s)
      灘浩樹
    • Organizer
      ACAM-CECAM Workshop on Molecular Simulation of Clathrate Hydrates
    • Place of Presentation
      University College Dublin(ダブリン)
    • Year and Date
      2010-05-06
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 氷核活性バクテリア存在下での氷結晶成長速度の異方性2010

    • Author(s)
      灘浩樹
    • Organizer
      日本物理学会第65回年次大会
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2010-03-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 氷核活性バクテリア存在下での氷結晶成長速度の異方性2010

    • Author(s)
      灘浩樹
    • Organizer
      日本物理学会第65回年次大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2010-03-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] バクテリア氷核タンパク質が氷の結晶成長に与える影響2009

    • Author(s)
      灘浩樹
    • Organizer
      第39回結晶成長国内会議
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] バクテリア氷核タンパク質が氷の結晶成長に与える影響2009

    • Author(s)
      灘浩樹
    • Organizer
      第39回結晶成長国内会議
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 氷核活性バクテリア存在下での氷の結晶成長2009

    • Author(s)
      灘浩樹
    • Organizer
      日本物理学会2009年秋季大会
    • Place of Presentation
      熊本大学(熊本)
    • Year and Date
      2009-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 氷核活性バクテリア存在下での氷の結晶成長2009

    • Author(s)
      灘浩樹
    • Organizer
      日本物理学会2009年秋季大会
    • Place of Presentation
      熊本大学
    • Year and Date
      2009-09-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] An experimental study of ice growth in the presence of ice nucleation-active bacteria2009

    • Author(s)
      灘浩樹
    • Organizer
      CRYO2009
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2009-07-20
    • Related Report
      2011 Final Research Report
  • [Presentation] An experimental study of ice growth in the presence of ice nucleation-active bacteria2009

    • Author(s)
      灘浩樹
    • Organizer
      CRYO2009
    • Place of Presentation
      北海道大学
    • Year and Date
      2009-07-20
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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