Highly Efficient Stereocontrol of 1, 3-Dipoles and Its Synthetic Application to Chiral Heterocycles
| Project/Area Number |
21550038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
UKAJI Yutaka 金沢大学, 物質化学系, 教授 (80193853)
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| Co-Investigator(Renkei-kenkyūsha) |
SOETA Takahiro 金沢大学, 物質化学系, 助教 (10506819)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 1, 3-双極子 / 立体制御 / 光学活性複素環化合物 / 付加環化反応骨格変換 / アゾメチンイミン / ニトロン / 酒石酸エステル / 1,3-双極子 / 付加環化反応 / 光学活性ピラゾリジン / 光学活性4-イソオキサゾリン / 光学活性α-アシルアジリジン / 不斉付加環化反応 / N-(プロパルギル)ヒドロキシルアミン |
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| Research Abstract |
Based on our concept of a novel chiral reaction system possessing multi-metal centers utilizing tartaric acid ester as a chiral auxiliary, a series of concerted asymmetric 1, 3-dipolar cycloaddition of azomethine imines and asymmetric nucleophilic addition of acetylides to nitrones followed by cyclization and rearrangement were developed to afford various types of optically active heterocycles.
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Report
(4 results)
Research Products
(119 results)
