Development of chemiluminescence probe using dioxetanes responsive to a conformational change
| Project/Area Number |
21550052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Kanagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Masakatsu 神奈川大学, 理学部, 教授 (10260986)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 有機光化学 / 化学発光 / ジオキセタン / 発光プローブ / 化学発光プローブ / 分子認識 |
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| Research Abstract |
An aryl-substituted dioxetane fused with N-acylpyrrolidine gave four conformational isomers due to rotation of an aryl ring around the bond joining it to a dioxetane ring and/or conformational isomerism of N-acyl group. These conformational isomers were found to become possible to be effectively isolated by design of the N-acyl group. The thus-isolated conformational isomers showed the unique chemiluminescence, the properties of which were significantly different from each other. A new dioxetane bearing a sterically congested bisnaphthol moiety was found to give chemiluminescence in the presence of a Mg alkoxide. Furthermore, the thermodynamic properties were clarified for chemiluminescent decomposition of benzothiazolylphenol-substituted dioxetanes.
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Report
(5 results)
Research Products
(45 results)
