Synthesis and characterization of composite metal complexes aiming at regulations of genetic information
Project/Area Number |
21550070
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Inorganic chemistry
|
Research Institution | Chuo University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KITAMURA Yusuke 中央大学, 理工学部, 助教 (80433019)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | DNA / 複合金属錯体 / 多核錯体 / DNAコンジュゲート / 抗癌活性 / 一塩基多形 / 複合化金属錯体 / 二核錯体 / カチオン性シッフ塩基錯体 / フェナントロリン / プロテインスプライシング反応 |
Research Abstract |
We have synthesized various mixed ligand and multinuclear metal complexes and analyzed the DNA binding structures、evaluating the DNA binding affinity and the cleavage activity. The results indicated that the composite metal complexes strengthened efficiently the interaction with DNA and enhanced the cleavage activity. In addition、some of the complexes have been found to show a new type of anticancer activity. We have also synthesized new DNA metal complex conjugates and succeeded in developing an efficient technique for the detection of DNA SNPs by making use of protein splicing reactions.
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Report
(4 results)
Research Products
(60 results)