New analytical method on channel transports across bilayer lipid membranes
| Project/Area Number |
21550079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIRAI Osamu 京都大学, 大学院・農学研究科, 准教授 (40355011)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 状態分析 / イオンチャネル / イオン透過 / 脂質二分子膜 / KAT1チャネル / アンホテリシンB / 電気的中性則 / 電気化学測定 / リポソーム / グラミシジンA / KAT 1チャネル |
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| Research Abstract |
New analytical method on channel transports across bilayer lipid membranes was proposed by considering mass balance and electroneutrality. When the ion channel serves in the membrane, not only the transport of the target ion but also those of coexsisting ions should be evaluated. The ion-transport property was not controlled by only the relation between the ion size and the pore-size of the ion channel. It was proved that the distribution coefficients of both the target ion and the counter ion and their diffusion coefficients within the membrane were important factors.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article]2009
Author(s)
Osamu Shirai, Shunsuke Ozaki, Jun Onishi, N. Kozai, Toshihiko Ohnuki and Kenji Kano
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Journal Title
Chemistry Letters
Volume: 38
Issue: 11
Pages: 1038-1039
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Selective Transport of Organic Acids across Bilayer Lipid Membranes in the Presence of Amphotericin B Channels2011
Author(s)
Takafumi Yamauchi, Ryuhei Matsumoto, Shuji Fujita, Hideki Sakai, Yoko Watanabe, Yuichi Tokita, Seiya Tsujimura, Osamu Shirai, Kenji Kano
Organizer
Shikata Discussion 2011
Place of Presentation
Awaji Yumebutai International Conference Center, Hyogo, Japan
Year and Date
2011-05-29
Related Report
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