Method Development for Assessing the Progression of Metabolic Syndrome by Multiplex-dynamic Analysis of Compounds of Biological Importance
| Project/Area Number |
21550089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
KUSU Fumiyo 東京薬科大学, 薬学部, 教授 (70057371)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | メタボリックシンドローム / コレステロール / 遊離脂肪酸 / 電気化学分析 / 分析科学 / 薬学 / 動脈硬化 / 糖尿病 / 血糖値 / イソフラボン / コレスタノール / 酸化ステロール / 心筋梗塞 / 低比重リポタンパク質 |
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| Research Abstract |
The multiplex analytical methods for determining compounds of biological importance were developed to examine the progression of metabolic syndrome. Dynamic analyses of plasma free fatty acids, cholesterol, and pathologically important sterols in animal model of disease were performed by sensitive and precise HPLC with electrochemical detection. Moreover, a novel analytical strategy based on statistics aspect was shown to be applicable to examine the interaction between free fatty acids and blood glucose level. It was concluded that the present methods were useful various kinetic studies in clinical fields.
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Report
(4 results)
Research Products
(29 results)
