Development of micro-flow sensing system for important biological materials

• Project/Area Number: 21550093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Aichi Institute of Technology
• Principal Investigator: SAKAI Tadao 愛知工業大学, 工学部, 教授 (30076038)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: マイクロフローセンシング / 生体負荷物質 / 病態診断 / スキルフリー / 同時注入 / 迅速混合 / SIEMAシステム / PC制御 / 自動分析装置 / テトラブロモフェノールブルー(TBPB) / アルブミン / 糖尿病 / ホルムアルデヒド / 硫酸ヒドロキシルアミン / 縮合反応 / 鉄-Phen錯体 / フローインジェクション法 / 工業排水 / ゼロエミッションシステム / 迅速分析 / シーケンシャルインジェクション分析 / 糖尿病疾患 / アルブミン(A),クレアチニン(C) / A / C比(ACR) / 全自動検出システム

Research Abstract

Micro-flow sensing systems were assembled for the urinary albumin and formaldehyde in the waste water. The proposed analytical techniques show some advantages on easy handling, less reagent consumption, fully automated operation, rapidity and reproducibility. The system is available for diagnosis and environmental analysis.

Research Products

• [Journal Article] 新規な同時注入/迅速混合流れ分析法による残留塩素の定量 (2012)
  • Author(s): 安藤詩茉, 手嶋紀雄, 酒井忠雄, 本水昌二
  • Journal Title: 分析化学 Volume: 61 Pages: 115-121
  • NAID: 10030135090
  • Peer Reviewed
• [Journal Article] Simultaneous injection effective mixing flow analysis of urinary albumin using dye-binding reaction (2012)
  • Author(s): Nuanlaor Ratanawimamwong, Kraingkrai Ponhong, Norio Teshima, Duangjai Nacapricha, Kate Grudpan, Tadao Sakai, Shoji Motomizu
  • Journal Title: Talanta Volume: (in press)(掲載確定) Pages: 115-121
  • DOI: 10.1016/j.talanta.2012.02.027
  • Peer Reviewed
• [Journal Article] Flow injection spectrophotometric determination of formaldehyde based on its condensation with hydroxylamine and subsequent redox reaction with iron(III)-ferrozine complex (2011)
  • Author(s): N. Teshima, S. K. M. Fernandez, M. Ueda, H. Nakai, T. Sakai
  • Journal Title: Talanta Volume: 84 Pages: 1205-1208
  • Peer Reviewed
• [Journal Article] Flow injection spectrophotometric determination of formaldehy de based on its condensation with hydroxylamine and subsequent redox reaction with iron(III)-ferrozine complex (2011)
  • Author(s): Norio Teshima, Sara Keiko Murase Fernandez, Minoru Ueda, Hirokazu Nakai, Tadao Sakai
  • Journal Title: Talanta Volume: 84 Issue: 5 Pages: 1205-1208
  • DOI: 10.1016/j.talanta.2010.12.019
  • Peer Reviewed
• [Journal Article] Flow injection determination of urinary protein using fluorescence quenching of tetraiodofluorescein (2011)
  • Author(s): Tadao Sakai, Norio Teshima, Toshiyuki Kato, Shuji Katoh, Weena Siangproh
  • Journal Title: J.Flow Injection Anal. Volume: 28 Pages: 120-123
  • NAID: 40019903869
  • Peer Reviewed
• [Journal Article] Simultaneous injection effective mixing analysis system for the determination of direct bilirubin in urinary samples (2011)
  • Author(s): K.Ponhong, N.Teshima, K.Grudpan, S.Motomizu, T.Sakai
  • Journal Title: Talanta Volume: 87 Pages: 113-117
  • DOI: 10.1016/j.talanta.2011.09.048
  • Peer Reviewed
• [Journal Article] Simultaneous Injection-Effective Mixing Analysis of Palladium (2010)
  • Author(s): N. Teshima, D. Noguchi, Y. Joichi, N. Lenghor, N. Ohno, T. Sakai, S. Motomizu
  • Journal Title: Anal. Sci.(Rapid Communications) Volume: 26 Pages: 143-144
  • NAID: 10026781589
  • Peer Reviewed
• [Journal Article] 硫酸ヒドロキシルアミンと鉄(III)-1, 10-フェナントロリン錯体を用いる排水中ホルムアルデヒドのフローインジェクション吸光光度分析 (2010)
  • Author(s): 中井洋和, 手嶋紀雄, 酒井忠雄
  • Journal Title: 分析化学 Volume: 59 Pages: 273-278
  • NAID: 10026475852
  • Peer Reviewed
• [Journal Article] Simultaneous Injection-Effective Mixing Analysis of Palladium (2010)
  • Author(s): N.Teshima, D.Noguchi, Y.Joichi, N.Lenghor, N.Ohno, T.Sakai, S.Motomizu.
  • Journal Title: Analytical Sciences Volume: 26 Pages: 143-144
  • NAID: 10026781589
  • Peer Reviewed
• [Journal Article] Highly sensitive determination of cadmium and lead in leached solutions from ceramic ware by graphite furnace atomic absorption spectrometry coupled with sequential injection-based solid phase extraction method (2010)
  • Author(s): M.Ueda, N.Teshima, T.Sakai, Y.Joichi, S.Momomizu.
  • Journal Title: Analytical Sciences Volume: 26 Pages: 597-602
  • NAID: 10026783657
  • Peer Reviewed
• [Journal Article] A Multiple Processing Hybrid Flow System for Analysis of Formalde hyde Contamination in Food (2010)
  • Author(s): S.Teerasong, N.Amornthammarong, K.Grudpan, N.Teshima, T.Sakai, D.Nacapricha, N.Ratanawimarnwong.
  • Journal Title: Analytical Sciences Volume: 26 Pages: 629-633
  • Peer Reviewed
• [Journal Article] Exploiting a simple water extract of a flower as a natural reagent for acidity assay using a lab-on-chip (2010)
  • Author(s): M.Ueda, S.Lapanantnoppakhun, W.Wongwilai, N.Teshima, T.Sakai, K.Grudpan.
  • Journal Title: J.Flow Injection Anal. Volume: 27 Pages: 57-60
  • Peer Reviewed
• [Journal Article] Automated stopped-in-dual-loop flow analysis system for catalytic determination of vanadium in drinking water (2009)
  • Author(s): N. Teshima, M. Kuno, M. Ueda, H. Ueda, S. Ohno, T. Sakai
  • Journal Title: Talanta Volume: 79 Issue: 2 Pages: 517-522
  • DOI: 10.1016/j.talanta.2009.04.018
  • Peer Reviewed
• [Journal Article] Alternative method for measurement of albumin/creatinine ratio using spectrophotometric sequential injection analysis (2009)
  • Author(s): W. Siangproh, N. Teshima, T. Sakai, S. Katoh, O. Chailapakul
  • Journal Title: Talanta Volume: 79 Issue: 4 Pages: 1111-1117
  • DOI: 10.1016/j.talanta.2008.12.068
  • Peer Reviewed
• [Journal Article] Auotmated stopped-in-loop flow analysis system for catalytic detemination of vanadium in drinking water (2009)
  • Author(s): N.Teshima, M.Kuno, M.Ueda, H.Ueda, S.Ohno, T.Sakai
  • Journal Title: Talanta 79 Pages: 517-522
  • Peer Reviewed
• [Journal Article] Alternative method for measurement of albumin/creatinine ratio usinh spectrometric sequential injection analysis (2009)
  • Author(s): W.Siangproh, N.Teshima, T.Sakai, S.Katoh, O.Chailapaku
  • Journal Title: Tanalta 79 Pages: 1111-1117
  • Peer Reviewed
• [Journal Article] Flow injection simultaneous determination of copper and iron in lubricating oil using a new spectrophotometer with dual light-emitting diode (2009)
  • Author(s): N.Teshima, T.Sakai, K.Higuchi, M.Takahashi, T.Komoda, K.Kurahasi, K.Grudpan
  • Journal Title: J.Flow Injection Anal. 26 Pages: 139-142
  • NAID: 40016978259
  • Peer Reviewed
• [Presentation] History of the Japanese Association for Flow Injection Analysis (JAFIA) (2011)
  • Author(s): T.Sakai
  • Organizer: Mini-Symposium on Flow Injection Analysis with Professor Gary D.Christian
  • Place of Presentation: 愛知工大、豊田市(Invited)
  • Year and Date: 2011-12-05
• [Presentation] Trace analyses of environmental pollutants utilizing flow-based techniques coupled with pre-concentration system (2011)
  • Author(s): T.Sakai
  • Organizer: 14^<th> Asian Chemical Congress 2011
  • Place of Presentation: Bangkok, Thailand(Invited)
  • Year and Date: 2011-09-06
• [Presentation] Hybrid flow analysis systems and their applications (2011)
  • Author(s): N.Teshima, N.Ratanawimarnwong, D.Nacapricha, T.Sakai
  • Organizer: 17^<th> International Conference on Flow Injection Analysis
  • Place of Presentation: Krakow, Poland
  • Year and Date: 2011-07-05
• [Presentation] Measurements of urinary compounds using alternative flow-based techniques (2011)
  • Author(s): T.Sakai, N.Teshima, K.Ponhong, K.Grudpan, W.Siangproh, N.Ratanawimarnwong, S.Motomizu
  • Organizer: 17^<th> International Conference on Flow Injection Analysis
  • Place of Presentation: Krakow, Poland(Invited, Keynote lecture)
  • Year and Date: 2011-07-04
• [Presentation] 流れ分析法の基礎及び先端技術 (2011)
  • Author(s): 酒井忠雄, 手嶋紀雄
  • Organizer: 三菱化学アナリテック2011 FIA
  • Place of Presentation: 明治安田生命大阪御堂筋ビル(招待)
  • Year and Date: 2011-05-27
• [Presentation] Automated Analytical System for Urinary Protein Using Flow-based Techniques (2011)
  • Author(s): Tadao Sakai, Norio Teshima, Weena Siangproh, Nuanlaor Ratanawimarnwong, Shoji Motomizu
  • Organizer: IUPAC International Congress on Analytical Sciences 2011(ICAS 2011)
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-05-25
• [Presentation] Automated analytical system for urinary protein using flow-based techniques (2011)
  • Author(s): T.Sakai, N.Teshima, W.Siangproh, N.Ratanawimarnwong, S.Motomizu
  • Organizer: IUPAC International Congress on Analytical Sciences 2011
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-05-25
• [Presentation] Cross injection systems for multi-determination of albumin, creatinine and glucose in human urine (2011)
  • Author(s): N.Choengchan, P.Inpota, N.Maneerat, D.Nacapricha, T.Sakai, N.Teshima
  • Organizer: IUPAC International Congress on Analytical Sciences 2011
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-05-24
• [Presentation] Hybrid flow injection-stopped in loop flow system for successive determination of hydroquinone and quinone (2011)
  • Author(s): N.Teshima, K.Mitamura, T.Sakai
  • Organizer: IUPAC International Congress on Analytical Sciences 2011
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-05-24
• [Presentation] Application of flow-based techniques to diabetic diagnosis (2010)
  • Author(s): Tadao Sakai, Kanchana Watla-iad, Weena Siangproh, Norio Teshima, Kate Grudpan, Orawon Chailapakul
  • Organizer: The 16^<th> International Conference on Flow Injection Analysis(ICFIA 2010)
  • Place of Presentation: Pataya, Thailand
  • Year and Date: 2010-04-27
• [Presentation] Utilization of simultaneous injection effective mixing analytical method (2010)
  • Author(s): T.Sakai, N.Teshima, D.Noguchi, N.Ratanawimarnwong, D.Nacapricha, S.Motomizu.
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Application of flow-based techniques to diabetic diagnosis (2010)
  • Author(s): T.Sakai, K.Watla-iad, W.Siangproh, N.Teshima, K.Grudpan, O.Chailapakul.
  • Organizer: 16thICFIA
  • Place of Presentation: Pattaya, Thai
• [Presentation] Exploiting simple water extracts of some flowers as natural reagent for acidity assay using flow analysis including lab-on-chip (2010)
  • Author(s): S.Lapanantnoppakhun, M.Ueda, W.Wongwilai, N.Teshima, T.Sakai, K.Grudpan.
  • Organizer: 16^<th> ICFIA
  • Place of Presentation: Pattaya, Thai
• [Presentation] ヒドロキシルアミンと金属錯体を用いる排水中ホルムアルデヒドのフローインジェクション吸光光度定量 (2010)
  • Author(s): 手嶋紀雄, 酒井忠雄
  • Organizer: 第71回分析化学討論会
  • Place of Presentation: 島根大学
• [Presentation] 同時注入/迅速混合分析法(SIEMA)を用いる残留塩素の定量 (2010)
  • Author(s): 安藤詩茉, 手嶋紀雄, 酒井忠雄
  • Organizer: 第29回分析化学中部夏期セミナー
  • Place of Presentation: 三重
• [Presentation] 陶磁器溶出液中のCd, Pbの自動オンライン固相抽出/グラファイトファーネス原子吸光分析 (2010)
  • Author(s): 上田実, 手嶋紀雄, 酒井忠雄, 本水昌二
  • Organizer: Separation Sciences 2010
  • Place of Presentation: 幕張
• [Presentation] 基礎講座流れ分析(フローインジェクション)FIAの基礎技術 (2010)
  • Author(s): 酒井忠雄
  • Organizer: Separation Sciences 2010
  • Place of Presentation: 幕張
• [Presentation] 同時注入/迅速混合流れ分析法(SIEMA)の提案 (2010)
  • Author(s): 手嶋紀雄, 野口大介, 城市康隆, N.Lenghor, 大野典子, 酒井忠雄, 本水昌二
  • Organizer: 東京コンファレンス
  • Place of Presentation: 幕張
• [Presentation] オンライン濃縮/ストップトインループフロー分析法による尿中バナジウム・クレアチニン比の測定 (2010)
  • Author(s): 手嶋紀雄, N.Ratanawimarnwong, D.Nacapricha, 酒井忠雄
  • Organizer: 日本分析化学会第59年会
  • Place of Presentation: 東北大学
• [Presentation] テトラヨードフルオレセインの消光反応を用いる尿タンパクのFIA (2009)
  • Author(s): 手嶋紀雄, 加藤敏幸, 酒井忠雄
  • Organizer: 第48回フローインジェクション分析講演会
  • Place of Presentation: 大阪府立大
  • Year and Date: 2009-11-27
• [Presentation] 新規水溶性発色試薬を用いる鉄のシーケンシャルインジェクション分析 (2009)
  • Author(s): 栗田千裕, 手嶋紀雄, 酒井忠雄, 喜納兼勇
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜大学
  • Year and Date: 2009-11-14
• [Presentation] Activities on Environment and Materials Group (2009)
  • Author(s): T.Sakai, N.Teshima, K.Grudpan, M.Polasek
  • Organizer: International symposium of the Frontier Research Project
  • Place of Presentation: 愛知工業大学
  • Year and Date: 2009-10-09
• [Presentation] Successive determination of iron and vanadium using automated stopped-in-loop flow analysis (2009)
  • Author(s): N.Ratanawimarnwong, N.Teshima, T.Sakai, D.Nacapricha
  • Organizer: 日本分析化学会第58年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2009-09-24
• [Presentation] オンライン前濃縮/グラファイトファーネス原子吸光分析による鉛、カドミウムの高感度分析 (2009)
  • Author(s): 上田実, 手嶋紀雄, 酒井忠雄, 本水昌二
  • Organizer: 日本分析化学会第58年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2009-09-24
• [Presentation] 同時注入/迅速混合分析法(SIEMA)によるPd(II)の吸光光度定量 (2009)
  • Author(s): 野口大介, 城市康隆, 大野典子, 手嶋紀雄, 酒井忠雄, 本水昌二
  • Organizer: 日本分析化学会第58年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2009-09-24
• [Presentation] Spectrophotometric determination of palladium by simultaneous injection-effective mixing analysis(SIEMA) (2009)
  • Author(s): N.Teshima, D.Noguchi, Y.Joichi, N.Ohno, T.Sakai, S.Motomizu
  • Organizer: Flow Analysis VI
  • Place of Presentation: Mallorca, Spain
  • Year and Date: 2009-09-15
• [Book] 役にたつフローインジェクション分析 (2009)
  • Author(s): 小熊幸一, 本水昌二, 酒井忠雄, 手嶋紀雄
  • Publisher: 医学評論社
• [Book] 役にたつフローインジェクション分析 (2009)
  • Author(s): 酒井忠雄, 小熊幸一, 本水昌二編著
  • Total Pages: 300
  • Publisher: 医学評論社
• [Book] 新しい地平をひらく分析手法の最前線 (2009)
  • Author(s): 北森編, 酒井・手嶋(分担執筆)
  • Total Pages: 195
  • Publisher: 化学同人
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  • URL: http://w.w.w.aitech.ac.jp/~analabo/
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  • URL: http://www.aitech.ac.jp/~analabo/
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  • URL: http://www.aitech.ac.jp/~analabo/