Development of Optically Active Amine Catalysts with a Propeller-like Chirality for Asymmetric Synthesis
| Project/Area Number |
21550105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
IRIE Ryo 熊本大学, 大学院・自然科学研究科, 教授 (70243889)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 有機化学 / 合成化学 / 不斉合成 / 有機触媒 / キラル配位子 / 遷移金属触媒 / 金属中心性不斉 / キラルアミン / 2,6-二置換ピペリジン / キラル四座配位子 / モリブデン錯体 / 不斉エポキシ化 / 2,6-トランス-二置換ピペリジン / 2,6-シス-二置換ピペリジ / 不斉有機触媒 / 金属錯体触媒 / 2,6-トランス-二置換ピベリジン / 2,6-シス-二置換ピベリジ |
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| Research Abstract |
New asymmetric cycloisomerization reactions catalyzed by chiral amines have been developed to produce useful optically active furan- and pyran-containing heterobiaryl compounds with axial chirality. Novel chiral carbasugars, which would exhibit unique bioactivities, were also synthesized by using base-catalyzed rearrangement of endoperoxide. Furthermore, unprecedented optically active transition metal complexes with chirality at metal were prepared from a chiral tripodal tetradentate ligand based on tertially amine bearing three different coordination groups.
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Report
(4 results)
Research Products
(33 results)
