Synthesis of Cationic Glycopolymer and Development of Sugar-Coated Polyplex for Gene Delivery Application
| Project/Area Number |
21550156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OBATA Makoto 山梨大学, 大学院・医学工学総合研究部, 准教授 (70343267)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ラジカル重合 / RAFT重合 / 糖質高分子 / 核酸キャリア |
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| Research Abstract |
We have performed the synthesis of novel cationic glycopolymer, which is synthetic polymer bearing carbohydrate moieties, and the evaluation of their functions as a gene carrier. Block copolymers of cationic monomer with vinyl monomer bearing D-mannose have been successfully synthesized by means of precisely controlled polymerization. Preliminary in vitro experiment afforded a key for the molecular architecture of the efficient cationic glycopolymer as gene carrier.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Syntheses of 3-Arm and 4-Arm Star-Branched Polystyrene Ru(II) Complexes by the Click-to-Chelate Approach2011
Author(s)
Chunhong Zhang, Xiande Shen, Ryosuke Sakai, Michael Gottschaldt, Ulrich S. Schubert, Shiho Hirohara, Masao Tanihara, Shigenobu Yano, Makoto Obata, Nao Xiao, Toshifumi Satoh, Toyoji Kakuchi
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Journal Title
J. Polym. Sci. Part A : Polym. Chem.
Volume: 49
Pages: 746-753
Related Report
Peer Reviewed
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[Journal Article] Oxygen-Sensing Properties of 5, 10, 15, 20-Tetraphenylporphinato Platinum(II) and Palladium(II) Covalently Bound on Poly(isobutyl-co-2, 2, 2-trifluoroethyl methacrylate2010
Author(s)
Makoto Obata, Noriko Matsuura, Kazunori Mitsuo, Hiroki Nagai, Keisuke Asai, Masafumi Harada, Shiho Hirohara, Masao Tanihara, Shigenobu Yano
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Journal Title
J. Polym. Sci. Part A : Polym. Chem.
Volume: 48
Pages: 663-670
Related Report
Peer Reviewed
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