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Control of composition and morphology of hollow hydroxyapatite microspheres and their application to dental implant materials releasing an antimicrobial agent

Research Project

Project/Area Number 21560712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Composite materials/Physical properties
Research InstitutionNiigata University

Principal Investigator

KIMURA Isao  新潟大学, 自然科学系, 教授 (00169921)

Co-Investigator(Kenkyū-buntansha) KANATANI Mitsugu  新潟大学, 医歯学系, 助教 (40177499)
TANAKA Takaaki  新潟大学, 自然科学系, 准教授 (00217043)
Co-Investigator(Renkei-kenkyūsha) AKAZAWA Toshiyuki  北海道立総合研究機構, 工業試験場, 材料化学科長 (80469692)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords複合粒子 / 無機質壁マイクロカプセル / 医用材料 / 生体材料 / 複合材料・物性 / 化学工学 / 歯学 / セラミックス
Research Abstract

Hollow microspheres of calcium phosphate compounds(such as hydroxyapatite, calcium hydrogen phosphate, etc.) were prepared by using multiple emulsions. The composition, morphology, and crystallinity were controlled by the addition of one of a magnesium salt, a carbonate, and low molecular weight organic compounds. For obtaining fundamental knowledge to apply the microspheres to dental implants which release an antimicrobial agent, the conditions for making them adhere onto titanium were investigated. A model implant was fabricated through the following procedures : the formation of microsphere layers on the surface of a titanium screw, the impregnation of a dye solution as the model material of an antimicrobial agent into the microsphere layer, and the coating with biodegradable polymer, poly(lactic acid). With the aim of applying the microspheres to a root canal treatment, composite microcapsules of the microspheres with biodegradable polymer were prepared.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (20 results)

  • [Journal Article] Effects of organic additives on the morphology of various calcium phosphates prepared via solution and emulsion methods2011

    • Author(s)
      I. Kimura, T. Wei, Y. Kikushima, R. E. Riman, T. Akazawa
    • Journal Title

      IOP Conference Series : Materials Science and Engineering

      Volume: 18巻 Issue: 19 Pages: 1-4

    • DOI

      10.1088/1757-899x/18/19/192017

    • NAID

      120006744623

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion of hollow calcium-deficient hydroxyapatite microspheres onto titanium2009

    • Author(s)
      I. Kimura, M. Kanatani, K. Watanabe
    • Journal Title

      Dental Materials Journal

      Volume: 28巻 Pages: 700-707

    • NAID

      10025917148

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of hollow hydroxyapatite microspheres containing magnesium or carbonate by using a multiple emulsion2009

    • Author(s)
      I. Kimura, H. Sato
    • Journal Title

      Archives of Bioceramics Research

      Volume: 7巻 Pages: 199-202

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion of hollow calcium-deficient hydroxyapatite microspheres onto titanium2009

    • Author(s)
      I.Kimura, M.Kanatani, K.Watanabe
    • Journal Title

      Dental Materials Journal 28巻

      Pages: 700-707

    • NAID

      10025917148

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of hollow hydroxyapatite microspheres containing magnesium or carbonate by using a multiple emulsion2009

    • Author(s)
      I.Kimura, H.Sato
    • Journal Title

      Archives of Bioceramics Research 7巻

      Pages: 199-202

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Preparation of hydroxyapatite/poly(lactic acid) composite microspheres in a W/O/W emulsion2011

    • Author(s)
      I. Kimura, S. Shibasaki, T. Tanaka
    • Organizer
      The 11th Asian Bioceramics Symposium
    • Place of Presentation
      つくば
    • Year and Date
      2011-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of hydroxyapatite/poly(lactic acid) composite microspheres in a W/O/W emulsion2011

    • Author(s)
      I.Kimura, S.Shibasaki, T.Tanaka
    • Organizer
      The 11th Asian Bioceramics Symposium
    • Place of Presentation
      物質材料研究機構(茨城県)
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 炭酸カルシウムの多形がリン酸カルシウム系化合物への転化に及ぼす効果2011

    • Author(s)
      阿部司,木村勇雄
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] W/O/W分散系における無機質ミクロスフィアの形成過程2011

    • Author(s)
      木村勇雄
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] W/O/W分散系における無機質ミクロスフィアの形成過程2011

    • Author(s)
      木村勇雄
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of organic additives on the morphology of various calcium phosphates prepared via solution and emulsion methods2010

    • Author(s)
      I. Kimura, T. Wei, Y. Kikushima, R. E. Riman, T. Akazawa
    • Organizer
      The 3rd International Congress on Ceramics
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of Organic Additives on the Morphology of Various Calcium Pho sphates Prepared via Solution and Emulsion Methods2010

    • Author(s)
      I.Kimura, T.Wei, Y.Kikushima, R.E.Riman, T.Akazawa
    • Organizer
      The 3rd International Congress on Ceramics
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 複合エマルションを利用するりん酸カルシウム化合物ミクロスフィアの調製第2報油相界面活性剤濃度の影響2010

    • Author(s)
      菊島祐太,木村勇雄
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      京都
    • Year and Date
      2010-09-07
    • Related Report
      2011 Final Research Report
  • [Presentation] W/O分散系の液滴径制御と無機質ミクロスフィア調製への応用2010

    • Author(s)
      野村智哉,木村勇雄
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      京都
    • Year and Date
      2010-09-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 複合エマルションを利用するりん酸カルシウム化合物ミクロスフィアの調製第2報油相界面活性剤濃度の影響2010

    • Author(s)
      菊島祐太・木村勇雄
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      同志社大学(京都府)
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 複合エマルションを利用するりん酸カルシウム化合物ミクロスフィアの調製第1報外水相界面活性剤濃度の影響2010

    • Author(s)
      菊島祐太,木村勇雄
    • Organizer
      化学工学会宇都宮大会
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-08-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 複合エマルションを利用するりん酸カルシウム化合物ミクロスフィアの調製第1報外水相界面活性剤濃度の影響2010

    • Author(s)
      菊島祐太・木村勇雄
    • Organizer
      化学工学会宇都宮大会
    • Place of Presentation
      宇都宮大学(栃木県)
    • Year and Date
      2010-08-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of hollow hydroxyapatite microspheres containing magnesium or carbonate by using a multiple emulsion2009

    • Author(s)
      I. Kimura, H. Sato
    • Organizer
      The 9th Asian Bioceramics Symposium
    • Place of Presentation
      名古屋
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of hollow hydroxyapatite microspheres containing magnesium or carbonate by using a multiple emulsion2009

    • Author(s)
      I.Kimura, H.Sato
    • Organizer
      9th Asian Bioceramics Symposium
    • Place of Presentation
      Nagoya Congress Center
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 界面反応法により調製したヒドロキシアパタイトミクロスフィアの溶解挙動2009

    • Author(s)
      木村勇雄,宮村健司
    • Organizer
      日本セラミックス協会東北北海道支部研究発表会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 界面反応法により調製したヒドロキシアパタイトミクロスフィアの溶解挙動2009

    • Author(s)
      木村勇雄・宮村健司
    • Organizer
      日本セラミックス協会東北北海道支部研究発表会
    • Place of Presentation
      北海道大学
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] カルシウム欠損型ヒドロキシアパタイト中空ミクロスフィアのチタンねじへの付着2009

    • Author(s)
      木村勇雄,金谷貢
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] カルシウム欠損型ヒドロキシアパタイト中空ミクロスフィアのチタンねじへの付着2009

    • Author(s)
      木村勇雄・金谷貢
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      かごれま県民交流センター
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 界面反応法によるマグネシウムおよび炭酸を含有するヒドロキシアパタイト粒子の調製2009

    • Author(s)
      佐藤悠正,木村勇雄
    • Organizer
      化学工学会米沢大会
    • Place of Presentation
      米沢
    • Year and Date
      2009-08-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 界面反応法によるマグネシウムおよび炭酸を含有するヒドロキシアパタイト粒子の調製2009

    • Author(s)
      佐藤悠正・木村勇雄
    • Organizer
      化学工学会米沢大会
    • Place of Presentation
      山形大学
    • Year and Date
      2009-08-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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