Assessment of bone biology using 3-D structured bone substitute manufactured by rapid prototyping technology

• Project/Area Number: 21560720
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: Kyoto University
• Principal Investigator: FUJIBAYASHI Shunsuke 京都大学, 医学研究科, 助教 (30362502)
• Co-Investigator(Renkei-kenkyūsha): ADACHI Taiji 京都大学, 再生医科学研究所, 教授 (40243323)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 生体内吸収材料 / 三次元構造 / 構造解析 / 経時的変化 / 熱溶融積層法

Research Abstract

3-D structured bone substitute was manufactured by rapid prototyping technology. Optimal 3-D structure of biomaterial for both osteoconduction and osteoinduction was assessed using animal model. The results of this study revealed that 1200-micron size pore was suitable for osteoconduction and 500-micron size pore was suitable for osteoinduction. And submicron-size surface structure was also important for bone ingrowth.

Research Products

• [Journal Article] Osteoinduction of porous Ti implants with channel structure fabricated by selective laser melting (2011)
  • Author(s): Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T.
  • Journal Title: Acta Biomater Volume: 7 Issue: 5 Pages: 2327-36
  • DOI: 10.1016/j.actbio.2011.01.037
  • Peer Reviewed
• [Journal Article] Bioactive Ti Metal Analogous to Human Cancellous Bone : Fabrication by Selective Laser Melting and Chemical Treatments (2011)
  • Author(s): Pattanayak DK, Fukuda A, Matsushita T, Takemoto M, Fujibayashi S, Sasaki K, Nishida N, Nakamura T, Kokubo T
  • Journal Title: Acta Biomater Volume: 7 Issue: 3 Pages: 1398-406
  • DOI: 10.1016/j.actbio.2010.09.034
  • Peer Reviewed
• [Journal Article] Bioactive Ti metal analogous to human cancellous bone : Fabrication by selective laser melting and chemical treatments (2011)
  • Author(s): Pattanayak DK, et al
  • Journal Title: Acta Biomater Volume: 7(3) Pages: 1398-406
  • Peer Reviewed
• [Journal Article] Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting (2011)
  • Author(s): Fukuda A, et al
  • Journal Title: Acta Biomater Volume: 7(5) Pages: 2327-36
  • Peer Reviewed
• [Journal Article] Reinforcement of tendon attachment to bioactive porous titanium by BMP-2-induced ectopic bone formation. (2010)
  • Author(s): So K., et al.
  • Journal Title: J Biomed Mater Res A Volume: 93(4) Pages: 1410-1416
  • Peer Reviewed
• [Journal Article] Positively charged bioactive Ti metal prepared by simple chemical and heat treatments (2010)
  • Author(s): Kokubo T., et al.
  • Journal Title: J R Soc Interface Volume: 6(7)Suppl
  • Peer Reviewed
• [Journal Article] 混酸加熱処理チタンの生体活性 (2010)
  • Author(s): 河井利之, 他
  • Journal Title: 日本整形外科学会雑誌 Volume: 84(8) Pages: 1087-1087
  • Peer Reviewed
• [Journal Article] 生体活性チタン多孔体による腰椎固定術、自主臨床試験の経験と今後の課題 (2010)
  • Author(s): 竹本充, 他
  • Journal Title: 日本整形外科学会雑誌 Volume: 84(4) Pages: 307-307
  • Peer Reviewed
• [Journal Article] P4 agonist accelerates osteoinduction and degradation of b-tricalcium phosphate by stimulating osteoclastogenesis (2009)
  • Author(s): Nasu T, et al
  • Journal Title: J. Biomed. Mater. Res. 89A Pages: 601-608
  • Peer Reviewed
• [Journal Article] AWガラスセラミック多孔体の気孔構造による骨形成への影響 (2009)
  • Author(s): 斉藤聡彦, 他
  • Journal Title: Orthopaedic Ceramic Implants 29 Pages: 9-11
• [Journal Article] 生体活性チタンの開発 -臨床応用に向けての課題- (2009)
  • Author(s): 藤林俊介, 他
  • Journal Title: 日整会誌 83 Pages: 469-474
  • NAID: 10026310720
• [Presentation] 生体活性多孔体チタンを用いた脊椎再建への試み (2010)
  • Author(s): 藤林俊介
  • Organizer: 第30回整形外科バイオマテリアル研究会
  • Place of Presentation: 京都テルサ(京都市)
  • Year and Date: 2010-12-04
• [Presentation] 混酸加熱処理チタンの生体活性 (2010)
  • Author(s): 河井利之
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-10-14
• [Presentation] 生体活性チタン多孔体による腰椎固定術、自主臨床試験の経験と今後の課題 (2010)
  • Author(s): 竹本充
  • Organizer: 第83回日本整形外科学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-05-29
• [Presentation] ガラスセラミックAW多孔体の骨誘導能と気孔構造による骨誘導能への影響 (2009)
  • Author(s): 斉藤聡彦, 他
  • Organizer: 第29回整形外科セラミック・インプラント研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-12
• [Presentation] Rapid prototypingで作製した生体活性処理レンコン状チタン材料の各孔におけるbone ingrowth評価 (2009)
  • Author(s): 福田明伸、藤林俊介、他
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-16
• [Presentation] Fujibayashi Set al : Bone Ingrowth into Pores of Lotus-type Bioactive Titanium Fabricated Using Rapid Prototyping (2009)
  • Author(s): Fukuda A
  • Organizer: Bioceramcs
  • Place of Presentation: Daegu
  • Year and Date: 2009-10-27
• [Presentation] Bone Ingrowth into Pores of Lotus-type Bioactive Titanium Fabricated Using Rapid Prototyping (2009)
  • Author(s): Fukuda A, et al
  • Organizer: Bioceramcs 22
  • Place of Presentation: Daegu, KoREA
  • Year and Date: 2009-10-27
• [Presentation] Fujibayashi Set al : Development of porous bioactive titanium by rapid prototyping (2009)
  • Author(s): Fukuda A
  • Organizer: 22nd European Conference on Biomaterials
  • Place of Presentation: LAUSANNE
  • Year and Date: 2009-09-09
• [Presentation] Development of porous bioactive titanium by rapid prototyping (2009)
  • Author(s): Fukuda A, et al
  • Organizer: 22nd European Conference on Biomaterials
  • Place of Presentation: LAUSANNE, SWiSS
  • Year and Date: 2009-09-09
• [Presentation] 酸化チタン被覆PETの骨結合能に関する研究 (2009)
  • Author(s): 斉藤聡彦, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
• [Presentation] 骨髄液のscaffoldとして多孔体複合体u-HA/PDLLAを用いたウサギ腰椎後側方固定術の検討 (2009)
  • Author(s): 田中耕次郎, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜