Development of Novel Vaccine Using Hybrid Liposomes for Cancer Therapy

• Project/Area Number: 21560813
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Sojo University
• Principal Investigator: GOTO Koichi 崇城大学, 生物生命学部, 教授 (30279377)
• Co-Investigator(Kenkyū-buntansha): UEOKA Ryuichi 崇城大学, 生物生命学部, 教授 (70099076)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 免疫学 / 癌 / リポソーム / ワクチン / T細胞

Research Abstract

The immunotherapeutic effects of hybrid liposomes(HL-MUC-1/mB7-1) composed of phospholipids(DMPC) and nonionic surfactants(Tween 80) including synthetic MUC-1 antigen peptides and recombinant mB7-1 proteins were examined. In vivo experiments, the prolonged survival was observed in mouse models with breast cancer cells after the treatment of HL-MUC1/mB7-1.The results suggested that HL-MUC1/mB7-1 could have the possibility of novel liposome vaccine for cancer therapy.

Research Products

• [Journal Article] Remarkable Inhibitory Effects of Hybrid Liposomes on Growth of Human Colon Cancer Cells through Induction of Cell Cycle Arrest along with Apoptosis (2011)
  • Author(s): Y. Komizu, H. Ueoka, K. Goto, R. Ueoka
  • Journal Title: International Journal of Nanomedicine Volume: 6巻 Pages: 1913-1920
  • Peer Reviewed
• [Journal Article] Selective Accumulation of Hybrid Liposomes into Adult T-Cell Leukemia Cells along with Induction of Apoptosis (2011)
  • Author(s): Y. Komizu, M. Yukihara, R. Kariya, K. Goto, S. Okada, R. Ueoka
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 21巻 Pages: 3962-3965
  • Peer Reviewed
• [Journal Article] Therapeutic Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Hepatic Metastasis of Colon Carcinoma along with Apoptosis in Vivo (2011)
  • Author(s): H. Ichihara, K. Zako, Y. Komizu, K. Goto, R. Ueoka
  • Journal Title: Biological & Pharmaceutical Bulletin Volume: 34巻 Pages: 901-905
  • NAID: 130000738069
  • Peer Reviewed
• [Journal Article] ハイブリッドリポソームを用いたアルツハイマー病治療に関する基礎研究 (2011)
  • Author(s): 座古恵子, 坂口磨姫, 古水雄志, 市原英明, 後藤浩一, 松本陽子, 上岡龍一
  • Journal Title: 薬学雑誌 Volume: 131巻 Pages: 775-782
  • NAID: 130000678860
  • Peer Reviewed
• [Journal Article] Effective Drug Delivery System for Duchenne Muscular Dystrophy Using Hybrid Liposomes Including Gentamicin along with Reduced Toxicity (2011)
  • Author(s): M. Yukihara, K. Ito, O. Tanoue, K. Goto, T. Matsushita, Y. Matsumoto, M. Masuda, S. Kimura, R. Ueoka
  • Journal Title: Biological & Pharmaceutical Bulletin Volume: 34巻 Pages: 712-716
  • NAID: 130000657785
  • Peer Reviewed
• [Journal Article] 温州みかん抽出物含有ハイブリッドリポソームの制がん効果に関する研究 (2011)
  • Author(s): 上岡秀嗣, 古水雄志, 後藤浩一, 上岡龍一
  • Journal Title: 化学工学論文集 Volume: 37巻 Pages: 271-276
  • NAID: 10029241754
  • Peer Reviewed
• [Journal Article] Membrane-Targeted Nanotherapy with Hybrid Liposomes for Tumor Cells Leading to Apoptosis (2011)
  • Author(s): Y. Komizu, S. Nakata, K. Goto, Y. Matsumoto, R. Ueoka
  • Journal Title: ACS Medicinal Chemistry Letters Volume: 2巻 Pages: 275-279
  • Peer Reviewed
• [Journal Article] イタドリ生理活性物質含有ハイブリッドリポソームのリンパ腫細胞に対する増殖抑制効果 (2011)
  • Author(s): 市原英明, 巽一喜, 後藤浩一, 松本陽子, 上岡龍一
  • Journal Title: 化学工学論文集 Volume: 37巻 Pages: 192-196
  • NAID: 10027970840
  • Peer Reviewed
• [Journal Article] Inhibitory Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Growth of Colon Cancer Cells along with Apoptosis and Differentiation (2011)
  • Author(s): K. Goto, K. Zako, Y. Komizu, R. Ueoka
  • Journal Title: Chemistry Letters Volume: 40巻 Pages: 90-92
  • NAID: 10027655436
  • Peer Reviewed
• [Journal Article] Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis (2011)
  • Author(s): Yuji Komizu
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 21 Issue: 13 Pages: 3962-3965
  • DOI: 10.1016/j.bmcl.2011.05.015
  • Peer Reviewed
• [Journal Article] Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis (2011)
  • Author(s): Y. Komizu, H. Ueoka, K. Goto, R. Ueoka
  • Journal Title: Int. J. Nanomedicine Volume: 6 Pages: 1913-1920
  • DOI: 10.2147/ijn.s24160
  • Peer Reviewed
• [Journal Article] Inhibitory Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Growth of Colon Cancer Cells along with Apoptosis and Differentiation (2011)
  • Author(s): Koichi Goto
  • Journal Title: Chemistry Letters Volume: 40 Pages: 90-92
  • NAID: 10027655436
  • Peer Reviewed
• [Journal Article] イタドリ生理活性物質含有ハイブリッドリポソームのリンパ腫細胞に対する増殖抑制効果 (2011)
  • Author(s): 市原英明
  • Journal Title: 化学工学論文集 Volume: 37 Pages: 192-196
  • Peer Reviewed
• [Journal Article] Membrane-targeted Nanotherapy with Hybrid Liposomes for Tumor Cells Leading to Apoptosis (2011)
  • Author(s): Yuji Komizu
  • Journal Title: ACS Medicinal Chemistry Letters Volume: 2 Pages: 275-279
  • Peer Reviewed
• [Journal Article] 温州みかん抽出物含有ハイブリッドリポソームの制がん効果に関する研究 (2011)
  • Author(s): 上岡秀嗣
  • Journal Title: 化学工学論文集 Volume: (印刷中)
  • NAID: 10029241754
  • Peer Reviewed
• [Journal Article] Effective Drug Delivery System for Duchenne Muscular Dystrophy Using Hybrid Liposomes Including Gentamicin along with Reduced Toxicity (2011)
  • Author(s): Mamiko Yukihara
  • Journal Title: Biological & Pharmaceutical Bulletin Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] ハイブリッドリポソームを用いたアルツハイマー病治療に関する基礎研究 (2011)
  • Author(s): 座古恵子
  • Journal Title: 薬学雑誌 Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Therapeutic Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Hepatic Metastasis of Colon Carcinoma along with Apoptosis in Vivo (2011)
  • Author(s): Hideaki Ichihara
  • Journal Title: Biological & Pharmaceutical Bulletin Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Clustering of Lipid Rafts in Plasma Membranes by Hybrid Liposomes for Leukemia Cells along with Apoptosis (2010)
  • Author(s): Y. Komizu, S. Nakata, K. Goto, Y. Matsumoto, R. Ueoka
  • Journal Title: Chemistry Letters Volume: 39巻 Pages: 1291-1293
  • NAID: 10027468549
  • Peer Reviewed
• [Journal Article] Clustering of Lipid Rafts in Plasma Membranes by Hybrid Liposomes for Leukemia Cells along with Apoptosis (2010)
  • Author(s): Yuji Komizu
  • Journal Title: Chemistry Letters Volume: 39 Pages: 1291-1293
  • Peer Reviewed
• [Presentation] ハイブリッドリポソームによるヒト骨肉腫細胞の浸潤抑制効果 (2011)
  • Author(s): 北島英樹
  • Organizer: 第15回日本がん分子標的治療学会学術集
  • Place of Presentation: ホテル日航東京
  • Year and Date: 2011-06-24
• [Presentation] ハイブリッドリポソームによるヒト骨肉腫細胞の浸潤抑制効果 (2011)
  • Author(s): 北島英樹
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2011-06-24
• [Presentation] Apoptotic mechanism of leukemia cells by hybrid liposomes in relation to fluctuation of membranes (2010)
  • Author(s): M. Ohgidani
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: 岡崎コンファレンスセンター
  • Year and Date: 2010-11-30
• [Presentation] Inhibitory effects of hybrid liposomes containing polyunsaturated fatty acids on the growth of tumor cells (2010)
  • Author(s): K. Goto
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: 岡崎コンファレンスセンター
  • Year and Date: 2010-11-30
• [Presentation] Clustering of lipid rafts in plasma membranes by hybrid liposomes for leukemia cells leading to apoptosis (2010)
  • Author(s): Y. Komizu
  • Organizer: The 4th International Symposium on Molecular Science of Fluctuations toward Biological Functions
  • Place of Presentation: ピアザ淡海
  • Year and Date: 2010-11-30
• [Presentation] Clustering of lipid rafts in plasma membranes by hybrid liposomes for leukemia cells leading to apoptosis (2010)
  • Author(s): Yuji Komizu
  • Organizer: The 4th International Symposium on Molecular Science of Fluctuations toward Biological Functions
  • Place of Presentation: ピアザ淡海(滋賀県)
  • Year and Date: 2010-11-30
• [Presentation] Inhibitory effects of hybrid liposomes containing polyunsaturated fatty acids on the growth of tumor cells (2010)
  • Author(s): Koichi Goto
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)(Invited Speaker)
  • Year and Date: 2010-11-30
• [Presentation] Apoptotic mechanism of leukemia cells by hybrid liposomes in relation to fluctuation of membranes (2010)
  • Author(s): Masahiro Ohgidani
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)
  • Year and Date: 2010-11-30
• [Presentation] Specific inhibitory effects of hybrid liposomes on the growth of HIV-latently infected cells and primary effusionlymphoma in vitro and in vivo (2010)
  • Author(s): K. Goto
  • Organizer: BIT's 1st World Congress of Virus and Infections-2010
  • Place of Presentation: 釜山
  • Year and Date: 2010-08-02
• [Presentation] Specific inhibitory effects of hybrid liposomes on the growth of HIV-latently infected cells and primary effusion lymphoma in vitro and in vivo (2010)
  • Author(s): Koichi Goto
  • Organizer: BIT's 1st World Congress of Virus and Infections-2010
  • Place of Presentation: Busan Exhibition & Convention Center(釜山)(Invited Speaker)
  • Year and Date: 2010-08-02
• [Remarks]
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