| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To clarify the tissue homeostasis mechanism of multicellular organisms, we analyzed the regeneration processes of adult and larval zebrafish tissues and obtained the following results.
1. The signaling pathway involving the Junb, Junbl and JNK has an essential role in regeneration.
2. To reveal the origin and fate of regenerating cells, we generated transgenic lines for cell fate tracing and cell ablation.
3. From the analysis of regeneration defective zebrafish mutant, we showed that a factor derived from the hematopoietic tissues is necessary for the survival of regenerating cells.
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