Understanding the novel interplay between telomere and helicase in chromosome maintenance
Project/Area Number |
21570006
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Genetics/Genome dynamics
|
Research Institution | Hiroshima University |
Principal Investigator |
MASARU Ueno 広島大学, 大学院・先端物質科学研究科, 准教授 (90293597)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | テロメア / 分裂酵母 / RecQヘリケース / 微小管重合阻害剤 / 染色体分配 / ヘリケース / DNA組換え |
Research Abstract |
The double mutants between fission yeast telomere binding protein Pot1 and Rqh1 helicase and the double mutant between fission yeast telomerase Trt1 and Rqh1 helicase are sensitive to microtubule drug TBZ. We found that the reason for the TBZ sensitivity is due to the accumulation of recombination intermediates at telomere in M phase, which inhibits chromosome segregation.
|
Report
(4 results)
Research Products
(27 results)
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[Journal Article] A Double Mutant between Fission Yeast Telomerase and RecQ Helicase Is Sensitive to Thiabendazole, an Anti-Microtubule Drug2012
Author(s)
S.Ukimori, N.Kawabata, H.Shimada, Ryota Imano, K.Takahashi, M.Yukawa, E.Tsuchiya, M.Ueno
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 76
Issue: 2
Pages: 264-269
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation2011
Author(s)
K. Takahashi, R. Imano, T. Kibe, H. Seimiya, Y. Muramatsu, N. Kawabata, G. Tanaka, Y. Matsumoto, T. Hiromoto, Y. Koizumi, N. Nakazawa, M. Yanagida, M. Yukawa, E. Tsuchiya, M. Ueno
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Journal Title
Mol. Cell. Biol
Volume: 31
Pages: 495-506
NAID
Related Report
Peer Reviewed
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