Analysis of RagA, B/C, D in mTOR signal transduction system
| Project/Area Number |
21570007
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Genetics/Genome dynamics
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 分子遺伝 / 遺伝学 / 遺伝子 / 環境 / 微生物 / シグナル伝達 |
|---|
| Research Abstract |
The objective of this research was to find when, where, and how the G proteins(RagA, B/C, D) regulate mTOR signal transduction pathway. Moreover, we tried to identify roles of interacting proteins of the G proteins in mTOR pathway.
We elucidated significance of Gtrlp and Gtr2p complex formation and interaction to other proteins(Ego3 and Egol) by using G protein mutant proteins.
We found that Gtrlp interacted to Torl complex proteins Kogl and Tco89 in a specific manner. Interaction between Gtrlp and Tco89p was important.
We showed that human RagA, C regulate mTOR and AMPK. It was shown that AMPK regulates mTOR. Here we found that RagA, C could be bridge proteins for mTOR and AMPK.
|
Report
(4 results)
Research Products
(27 results)
-
[Journal Article] 2011 Ubiquitin chains in the DSK2 UBL domain mediate DSK2 stability and protein degradation in Yeast2011
Author(s)
Sekiguchi, T., Sasaki, T., Funakoshi, M., Ishii, T., Saitoh, Y., Kaneko, S., Kobayashi, H.
-
Journal Title
Biochem. Biophys. Res. Commun
Volume: 411
Pages: 555-561
Related Report
-
-
-
[Journal Article] 2010 New methods for species and sex determination in three sympatric Mustelids, Mustela itatsi
Author(s)
ekiguchi T, Sasaki H, Kurihara Y, Watanabe S, Moriyama D, Kurose N, Matsuki R, Yamazaki K, Saeki M.
-
Journal Title
Mustela sibirica, and Martes me/ampus Mol. Eco. Res
Volume: 10
Pages: 1089-1091
Related Report
-
[Journal Article] 2009 The Gtr 1 p associated with Gtr2p and with Egol p differently
Author(s)
Wang, YG., Kurihara, Y., Sato, T., Toh, H., Kobayashi, H. and Sekiguchi, T.
-
Journal Title
Gene
Volume: 437
Pages: 32-38
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
