Establishment and erasure of genomic imprinting during somatic and germline differentiation
| Project/Area Number |
21570009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Jichi Medical University (2010-2011)
The Institute of Physical and Chemical Research (2009) |
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Principal Investigator |
MISE Nathan 自治医科大学, 医学部, 助教 (00360644)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ゲノム刷り込み / DNAメチル化 / ES細胞 / 試験管内分化系 / 遺伝子発現 / エピジェネティクス / 細胞分化 / 生殖細胞分化 / ヒストン修飾 / EG細胞 / SNPs |
|---|
| Research Abstract |
Genomic imprinting is a gene regulatory mechanism in which genes only derived from one parent to work. Genomic imprinting is known to be regulated by DNA methylation, but detail molecular mechanisms establishing parent-of-origin dependent gene expression pattern is still unclear. In this study, we showed that the expression pattern of imprinted gene is established accompanying cell differentiation using with an ES cell in vitro differentiation system. We further established a in vitro cell culture system to analyze detailed molecular mechanisms of establishment of imprinted expression pattern of imprinted genes.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation2010
Author(s)
Chow J. C., Ciaudo C., Fazzari M. J., Mise N., Servant N., Glass J. L., Attreed M., Avner P., Wutz A., Barillot E., Greally J. M., Voinnet O., Heard E
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Journal Title
Cell
Volume: 141
Pages: 956-969
Related Report
Peer Reviewed
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[Journal Article] A high-speed congenic strategy using first-wave male germ cells2009
Author(s)
Ogonuki N, Inoue K, Hirose M, Miura I, Mochida K, Sato T, Mise N, Mekada K, Yoshiki A, Abe K, Kurihara H, Wakana S, Ogura A
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A high-speed congenic strategy using first-wave male germ cells2009
Author(s)
Ogonuki N, Inoue K, Hirose M, Miura I, Mochida K, Sato T, Mise N, Mekada K, Yoshiki A, Abe K, Kurihara H, Wakana S, Ogura A.
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Journal Title
Related Report
Peer Reviewed
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