Molecular mechanism of mRNA degradation induced by translation arrest in plants
| Project/Area Number |
21570032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ONOUCHI Hitoshi 北海道大学, 大学院・農学研究院, 准教授 (50322839)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 翻訳制御 / mRNA分解制御 / 上流ORF / 翻訳アレスト / mRNA分解 / 新生ペプチド / リボソーム / シロイヌナズナ / NMD |
|---|
| Research Abstract |
In plants, it has not been known whether mRNAs with stalled ribosomes are subject to mRNA surveillance. In this study, using Arabidopsis upstream open reading frames, we found that ribosome stalling caused by the uORF-encoded peptides promotes mRNA degradation by the nonsense-mediated mRNA decay pathway in Arabidopsis
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Report
(4 results)
Research Products
(29 results)
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[Presentation] Nascent peptide-mediated control of gene expression in Arabidopsis : Feedback regulation of methionine biosynthesis and beyond2011
Author(s)
Hitoshi Onouchi, Isao Ebina, Mariko Takemoto, Shun Watanabe, Noriyuki Onoue, Yui Yamashita, Yayoi Endo, Hiroaki Koyama, Yoko Yamashita-Nagami, Hiro Takahashi, Satoshi Naito
Organizer
12th International Congress on Amino Acids, Peptides and Protein
Place of Presentation
Beijing, China
Year and Date
2011-08-04
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