Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
Elongation factor G, a key protein in translation elongation, was inactivated via the formation of an intramolecular disulfide bond between two specific cysteine residues under oxidative conditions in the cyanobacterium Synechocystissp. PCC 6803. Reduction of the disulfide bond by thioredoxin resulted in the reactivation of EF-G, suggesting that translation might be regulated by the reducing power derived from the photosynthetic electron transport. Replacement of the target cysteine residue of EF-G by serine in Synechocystiscells protected photosystem II from photoinhibition.
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