| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Research Abstract |
Circadian phosphorylation rhythm of cyanobacterial clock protein KaiC can be reconstituted in vitro by mixing KaiC with KaiA and KaiB in the presence of ATP. The period of the rhythm is compensated for the changes in the ambient temperature. In this study, we clarified that the phosphorylation rhythm of KaiC results from repeating synthesis and degradation of ATP. The higher the temperature, the equilibrium was more favorable to ATP formation. These results can serve as important clues to elucidate the mechanism for temperature compensation of circadian period.
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