Gonadal plasticity of DMRT1 mutants in the medaka
| Project/Area Number |
21570059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Utsunomiya University |
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Principal Investigator |
MATSUDA Masaru 宇都宮大学, バイオサイエンス教育研究センター, 准教授 (20414013)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 形態形成 / 生殖腺性分化 / メダカ / 性決定 / DMRT1遺伝子 / 性差形成機構 |
|---|
| Research Abstract |
Dmrt1, which is found in many verte brates, exhibits testis-specific expression during the sexual differentiation period, suggesting a conserved function of Dmrt1 in the testicular development of vertebrate gonads. However, functional analyses have been reported only in mammals. The current study focused on the Dmrt1 function in the teleost medaka, Oryzias latipes, which has an XX-XY sex determina tion system. Although medaka sex is determined by the presence or absence of the Y chromosome-specific gene Dmy, we demonstrated that in one Dmrt1 mutant line, which was found by screening a gene-driven mutagenesis library, XY mutants developed into nor mal females and laid eggs. These results show that Dmrt1 is essential to maintain testis differentiation after Dmy-triggered male differentiation pathway.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Analysis of Sexually Dimorphic Expression of Genes at Early Gonadogenesis of Pejerrey Odontesthes bonariensis Using a Heterologous Microarray2011
Author(s)
Fernandino JI, Popesku JT, Paul-Prasanth B, Xiong H, Hattori RS, Oura M, Strussmann CA, Somoza GM, Matsuda M, Nagahama Y, Trudeau VL
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Journal Title
Sex Dev
Volume: 5
Pages: 89-101
Related Report
Peer Reviewed
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[Journal Article] Analysis of Sexually Dimorphic Expression of Genes at Early Gonadogenesis of Pejerrey Odontesthes bonariensis Using a Heterologous Microarray2011
Author(s)
Fernandino JI, Popesku JT, Paul-Prasanth B, Xiong H, Hattori RS, Oura M, Strussmann CA, Somoza GM, Matsuda M, Nagahama Y, Trudeau VL
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Journal Title
Sexual Development
Volume: 5
Issue: 2
Pages: 89-101
DOI
Related Report
Peer Reviewed
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