Study of mechanism in starfish oocyte maturation induced by a novel identified gonad-stimulating hormone
| Project/Area Number |
21570063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Tokyo Gakugei University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 生殖腺刺激ホルモン / リラキシン / シグナル情報伝達機構 / 卵成熟 / ヒトデ / Gsα |
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| Research Abstract |
According to in situ hybridyzation, gonad-stimulating hormone(GSS) newly identified in starfish was synthesized in supporting cells in the peripheral area of radial nerves proximal to the tube feet. Its secretion was induced by increase in levels of intracellular Ca^<2+>. This study also showed that GSS failed to induce 1-methyladenine(1-MeAde) and cAMP production by follicle cells obtained from ovaries in growing stage(stage IV), though GSS acted on 1-MeAde production mediated through the production of cAMP by follicle cells in fully grown stage(stage V). Since Gs. was not detected immunologically in follicle cell membranes of stage IV, the failure of GSS to produce 1-MeAde is possible to be because of a lack of Gs-proteins in follicle cells at stage IV.
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Report
(4 results)
Research Products
(54 results)
