| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We have clarified the subcellular distribution of Tektin2, Tektin3, Tektin4, Tektin5 in rat and mouse spermatozoa. Tektin2 is localized around outer dense fiber(ODF), Tektin3 is on the surface of mitochondria and ODF. Tektin4 is on the surface of ODF cortex, and Tektin5 is present on the inner surface of mitochondria in the middle piece od flagella. By yeast Two-Hybrid system, we isolated a novel molecule Tek2-BP1 as Tekitn2-interacting molecule as well as Tektin4 and Odf1 as a Tekitn5-interacting molecule. We found that Tek2-BP1 is localized on mitochondria of mouse sperm flagella.
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