Ultrastructural analysis of newly indentified membrane structure in autophagy
| Project/Area Number |
21570069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Kogakuin University (2010-2011)
Japan Women's University (2009) |
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Principal Investigator |
BABA Misuzu 工学院大学, 総合研究所, 研究員 (80435528)
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| Co-Investigator(Renkei-kenkyūsha) |
BABA Norio 工学院大学, 情報工学部, 教授 (80164896)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 免疫電子顕微鏡 / 電子線トモグラフイ / オートファジー / タンパク質分解 / 酵母細胞 / 微細構造 / 電子線トモグラフィ / 電子線トモグラィ |
|---|
| Research Abstract |
Autophagy is one of the intracellular degradative process. In this process, cells sequester their own cytoplasmic components into a novel double-membrane structure which is newly formed in cytoplasm, and then transport it into the lytic compartment for the reuse. Autophagy defective yeast mutants were isolated by genetic screening. To investigate how these membrane structures are generated during autophagy, I observed intracellular structure of autophagy defective mutants by using an electron microscope. As a result, I found the initial stage of this membrane structure.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] SNARE proteins are required for macroautophagy2011
Author(s)
Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen WL, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia J, Klionsky DJ
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Journal Title
Cell
Volume: Vol.146
Pages: 290-302
URL
Related Report
Peer Reviewed
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[Journal Article] SNARE proteins are required for macroautophagy2011
Author(s)
Nair U, Jotwani A, Gene J, Gammoh N, Richerson D, Yen WL, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia J, Klionsky DJ
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Journal Title
Cell
Volume: 146
Issue: 2
Pages: 290-302
DOI
Related Report
Peer Reviewed
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