| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Change of estrogen receptor α(ERα) in the neurons of the brain is an important to control reproductions such as ovulatory cycle in rats. In this experiment, it has been shown that degree of down-regulation of ERα by estrogen is different among regions of the brain or sexes, and ERα plays an important role in sexual differentiation of the brain functions. Furthermore, expression of ERα is influenced by serotonergic neurons. Serotonergic neurons itself have a sex difference and have a role to prevent irregular ovulatory cycle induced by a physical stress.
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