Control of estrogen receptor expression by serotonergic neurons in the raphe nuclei
Project/Area Number |
21570070
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphology/Structure
|
Research Institution | Waseda University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 神経内分泌 / 縫線核 / セロトニン神経 / エストロゲン受容体α / エストロゲン受容体β / ストレス / 性周期 / 運動負荷 / 代償性卵巣肥大 / 性差 / 部位差 / ダウンレギュレーション / 視床下部 / 中脳中心灰白室 |
Research Abstract |
Change of estrogen receptor α(ERα) in the neurons of the brain is an important to control reproductions such as ovulatory cycle in rats. In this experiment, it has been shown that degree of down-regulation of ERα by estrogen is different among regions of the brain or sexes, and ERα plays an important role in sexual differentiation of the brain functions. Furthermore, expression of ERα is influenced by serotonergic neurons. Serotonergic neurons itself have a sex difference and have a role to prevent irregular ovulatory cycle induced by a physical stress.
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Report
(4 results)
Research Products
(49 results)