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Formation of sexually dimorphic neural circuitry and its function in the Drosophila chemosensory system

Research Project

Project/Area Number 21570072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionHokkaido University of Education

Principal Investigator

KIMURA Ken-ichi  北海道教育大学, 教育学部, 教授 (80214873)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords昆虫 / 行動学 / 脳・神経 / 遺伝子 / ショウジョウバエ / 性行動 / 性決定
Research Abstract

In Drosophila melanogaster, sexually dimorphic projection pattern is seen in the taste neurons on tarsus of the forelegs. We identified the projection pattern of each taste neuron. Results showed that the neurons with some specific bristles in males have male-typical projection. Two sex determination factors, Fruitless and Doublesex, regulate the formation of male-specific projection pattern. Loss of function of Fruitless or Doublesex caused males having female-type of the projection pattern. They showed the normal activity of courtship still.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (54 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (38 results) Book (4 results)

  • [Journal Article] Apoptosis controls the speed oflooping morphogenesis in Drosophila maleterminalia2011

    • Author(s)
      Kuranaga E, Matsunuma T, Kanuka H, Takemoto K, Koto A, Kimura K-I, Miura M.
    • Journal Title

      Development

      Volume: 138 Pages: 1493-1499

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of cell death in the formation of sexual dimorphism in theDrosophila central nervous system2011

    • Author(s)
      Kimura K-I.
    • Journal Title

      Dev.Growth & Different

      Volume: 53 Pages: 236-244

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia2011

    • Author(s)
      Kuranaga, E., Matsunuma, T., Kanuka, H., Takemoto, K., Koto, A., Kimura, K-I., Miura, M.
    • Journal Title

      Development

      Volume: 138 Pages: 1493-1499

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of cell death in the formation of sexual dimorphism in the Drosophila central nervous system2011

    • Author(s)
      Ken-ichi Kimura
    • Journal Title

      Development, Growth & Differentiation

      Volume: 53 Pages: 236-244

    • NAID

      10027900407

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of cell death in the formation of sexual dimorphism in theDrosophila central nervous system2010

    • Author(s)
      Nojima T, Kimura K-I, Koganezawa M, Yamamoto D.
    • Journal Title

      Curr. Biol.

      Volume: 20 Pages: 836-840

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal Synaptic Outputs Determine the Sexual Fate of Postsynaptic Targets2010

    • Author(s)
      Tetsuya Nojima, Ken-ichi Kimura, Masayuki Koganezawa, Daisuke Yamamoto
    • Journal Title

      Current Biology

      Volume: 20 Pages: 836-840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The shaping of Drosophila male courtship posture by a gustatory pheromone2009

    • Author(s)
      Koganezawa, M, Matsuo Y, Kimura K-I, Yamamoto D.
    • Journal Title

      Annals of the NewYork Academy of Sciences

      Volume: 1170 Pages: 497-501

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development2009

    • Author(s)
      Sakurai M, Aoki T, Yoshikawa S, Santschi LA, Saito H, Endo K, Ishikawa K, Kimura K, Ito K, Thomas JB, Hama C.
    • Journal Title

      J. Neurosci.

      Volume: 19 Pages: 4972-4980

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multidendritic sensory neurons in the adult Drosophila abdomen2009

    • Author(s)
      Shimono K, Fujimoto A, Tsuyama T, Yamamoto-Kochi M, Sato M, Hattori Y, Sugimura K, Usui T, Kimura K-I, Uemura T.
    • Journal Title

      origins, dendritic morphology, and segment and age-dependent programmed cell death

      Volume: Neural Develop. 4 Pages: 37-37

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The shaping of Drosophila male courtship posture by a gustatory pheromone.2009

    • Author(s)
      Koganezawa, M.
    • Journal Title

      Annals of the New York Academy of Sciences 1170

      Pages: 497-501

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentially expressed Dr1 and Dr1-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development2009

    • Author(s)
      Sakurai M
    • Journal Title

      Journal of Neuroscience 19

      Pages: 4972-4980

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multidendritic sensory neurons in the adult Drosophila abdomen : origins, dendritic morphology, and segment- and age-dependent Programmed cell death2009

    • Author(s)
      Shimono K.
    • Journal Title

      Neural Development 4

      Pages: 37-37

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自己組織化プロセスの発生遺伝学的検討2012

    • Author(s)
      木村賢一
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(招待講演)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエ成虫脳における性決定因子doublesex 発現ニューロン群に見られる性差2011

    • Author(s)
      木村賢一,小金澤雅之,佐藤千晶,山元大輔
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ成虫脳における性決定因子doublesex発現ニューロン群に見られる性差2011

    • Author(s)
      木村賢一, 小金澤雅之, 佐藤千晶, 山元大輔
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sexually dimorphic taste neurons on the forelegs in Drosophila melanogaster2011

    • Author(s)
      Ken-ichi Kimura, Akira Urushizaki, Chiaki Sato, Rie Matsuda, Daisuke Yamamoto
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      チェンタン青年活動センター(台湾)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自己組織化プロセスの発生遺伝学的検討2011

    • Author(s)
      木村賢一
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      日本化学会第91春季年会(2011)講演予稿集 招待講演
    • Year and Date
      2011-03-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「細胞の死」と「いきものの生」-ハエのハネ、おしり、そして脳-2011

    • Author(s)
      木村賢一
    • Organizer
      第46回氷雪セミナー
    • Place of Presentation
      日本分化学会北海道支部
    • Year and Date
      2011-01-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 「細胞の死」と「いきものの生」-ハエのバネ、おしり、そして脳-2011

    • Author(s)
      木村賢一
    • Organizer
      日本分析化学会北海道支部第46回氷雪セミナー
    • Place of Presentation
      小樽 招待講演
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sexually dimorphic projection patterns of gustatory neurons in Drosophila forelegs2011

    • Author(s)
      Kimura K-I, Urushizaki A, Sato C, Matsuda R, Yamamoto D.
    • Organizer
      8th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2011 Final Research Report
  • [Presentation] Sexually dimorphic taste neurons on the forelegs in Drosophila melanogaster2011

    • Author(s)
      Kimura K-I, Urushizaki A, Sato C, Matsuda R, Yamamoto D.
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      チェンタン青年活動センター (台湾)
    • Related Report
      2011 Final Research Report
  • [Presentation] Sexually dimorphic projection patterns of gustatory neurons in Drosophila forelegs2011

    • Author(s)
      Ken-ichi Kimura, Akira Urushizaki, Chiaki Sato, Rie Matsuda, Daisuke Yamamoto
    • Organizer
      8th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center (Japan)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuronal synaptic outputs determine the sexual fate of postsynaptic targets2010

    • Author(s)
      Nojima T, Kimura K-I, Koganezawa M, Yamamoto D.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2011 Final Research Report
  • [Presentation] Fruitless and Doublesex cooperate to specify the sexual dimorphism in Drosophila taste neurons2010

    • Author(s)
      Kimura K-I, Urushizaki A, Sato C, Yamamoto D.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Related Report
      2011 Final Research Report
  • [Presentation] Sexually dimorphic taste neurons on the forelegs in Drosophila melanogaster2010

    • Author(s)
      漆崎彬、松田理恵、山元大輔、木村賢一
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuronal synaptic outputs determine the sexual fate of postsynaptic targets2010

    • Author(s)
      Nojima, T., Kimura, K., Koganezawa, M., and Yamamoto, D.
    • Organizer
      13th European Drosophila Neurobiology Conference "Neurofly"2010"
    • Place of Presentation
      Manchester (UK)
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ前肢-節味覚ニューロンの中枢投射パターンにおける雌雄差2010

    • Author(s)
      漆崎彬、松田理恵、山元大輔、木村賢一
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエの雄は求愛中どの感覚情報で雌の前後を見分けるか2010

    • Author(s)
      木村賢一,山本佳奈,佐藤千晶,山元大輔
    • Organizer
      日本比較生理生化学会大32回大会
    • Place of Presentation
      九州産業大学
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエの雄は求愛中どの感覚情報で雌の前後を見分けるか2010

    • Author(s)
      木村賢一, 山本佳奈, 佐藤千晶, 山元大輔
    • Organizer
      日本比較生理生化学会大32回大会
    • Place of Presentation
      九州産業大学(福岡市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエ前肢附節味覚ニューロンの中枢投射パターンにおける雌雄差2010

    • Author(s)
      漆崎彬・松田理恵、山元大輔、木村賢一
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal synaptic outputs determine the sexual fate of postsynaptic tarels.2010

    • Author(s)
      Nojima, T., Kimura, K., Kogane zawa,M., Yamamoto,D.
    • Organizer
      13th European Drosophila Neurobiology Conferenc e"Neurofly 2010"
    • Place of Presentation
      Manchester, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sexually dimorphic taste neurons on the forelegs in Drosophila melanogaster2010

    • Author(s)
      漆崎彬・松田理恵、山元大輔、木村賢一
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fmitless and Doublesex cooperate to specify the sexual dimorphism in Drosophila taste neurons2010

    • Author(s)
      Ken-ichi Kimura, Akira Urushizaki, Chiaki Sato, Daisuke Yamamoto
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal synaptic outputs determine the sexual fate of postsynaptic targets.2010

    • Author(s)
      Nojima, T., kimura, K., Kogane zawa, M., Yamamoto,D
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエ性決定因子Fruitlessによる味覚感覚ニューロンの性特異的投射パターンの形成2009

    • Author(s)
      木村賢一、漆崎彬、松田理恵、山元大輔
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ前肢味覚感覚ニューロンの中枢投射パターンにおける性差2009

    • Author(s)
      漆崎彬、松田理恵、山元大輔、木村賢一
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Multidendritic sensory neuorns in the adult Drosophila abdomen : origins, dendritic remodeling, and lifelong maintenance of dendritic arbors2009

    • Author(s)
      下野耕平、木村賢一、藤本梓、津山泰一、碓井理夫、上村匡
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ運動神経系の性差形成-雄特異筋を支配する運動神経2009

    • Author(s)
      木村賢一、山元大輔
    • Organizer
      第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ前肢味覚感覚ニューロンにおける性差-中枢投射パターン2009

    • Author(s)
      漆崎彬、松田理恵、山元大輔、木村賢一
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡大学
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエ前肢味覚感覚ニューロンにおける性差-性決定因子による性差形成2009

    • Author(s)
      木村賢一、漆崎彬、松田理恵、山元大輔
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Multidendritic sensory neuorns in the adult Drosophila abdomen : origins,dendritic remodeling, and life-long maintenance of dendritic arbors2009

    • Author(s)
      Shimono K, Kimura K-I, Fujimoto A, Tsuyama T, Usui T, Uemura T.
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      つま恋
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of a motoneuron innervatingthe male specific muscle (Muscle ofLawrence)2009

    • Author(s)
      Kimura K-I, Yamamoto D.
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      つま恋
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of a motoneuron innervating the male specific muscle(Muscle of Lawrence)2009

    • Author(s)
      Ken-ichi Kimura
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      つま恋(静岡)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multidendritic sensory neuorns in the adult Drosophila abdomen : origins, dendritic remodeling, and life-long maintenance of dendritic arbors2009

    • Author(s)
      Kohei Shimono
    • Organizer
      The 9th Japanese Drosophila Research Conference
    • Place of Presentation
      つま恋(静岡)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ前肢味覚感覚ニューロンにおける性差-(1)中枢投射パターン2009

    • Author(s)
      漆崎彬
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡大学(静岡市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ前肢味覚感覚ニューロンにおける性差-(2)性決定因子による性差形成2009

    • Author(s)
      木村賢一
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡大学(静岡市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ運動神経系の性差形成-雄特異筋を支配する運動神経2009

    • Author(s)
      木村賢一
    • Organizer
      第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multidendritic sensory neuorns in the adult Drosophila abdomen : origins, dendritic remodeling, and life-long maintenance of dendritic arbors2009

    • Author(s)
      下野耕平
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ前肢味覚感覚ニューロンの中枢投射パターンにおける性差2009

    • Author(s)
      漆崎彬
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ性決定因子Fruitlessによる味覚感覚ニューロンの性特異的投射パターンの形成2009

    • Author(s)
      木村賢一
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2009 Annual Research Report
  • [Book] シーエムシー出版 (東京)2011

    • Author(s)
      木村賢一
    • Publisher
      昆虫クチクラ形成の発生遺伝学的検討「次世代バイオミメティクス研究の最前線-生物多様性に学ぶ」
    • Related Report
      2011 Final Research Report
  • [Book] 昆虫クチクラ形成の発生遺伝学的検討「次世代バイオミメティクス研究の最前線-生物多様性に学ぶ」(下村政嗣編)2011

    • Author(s)
      木村賢一
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] 羊土社 (東京)2010

    • Author(s)
      木村賢一
    • Publisher
      脳の性差形成と細胞死「細胞死研究 総集編」(三浦正幸 編) 第4章発生における細胞死
    • Related Report
      2011 Final Research Report
  • [Book] 脳の性差形成と細胞死「細胞死研究総集編」三浦正幸編集第4章発生における細胞死2010

    • Author(s)
      木村賢一
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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