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Transgenic analyses of retinal photoreceptor neurons regulating teleost body color change.

Research Project

Project/Area Number 21570073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionThe University of Tokyo

Principal Investigator

KOJIMA Daisuke  東京大学, 大学院・理学系研究科, 講師 (60376530)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords体色変化 / ゼブラフィッシュ / 網膜 / オプシン / 視細胞 / 色素胞 / 光 / トランスジェニック
Research Abstract

Light-induced body color change, or background adaptation, in teleosts is regulated by retinal photoreceptor neurons. To identify the photoreceptor neurons, we established a real-time and quantitative monitoring system for body color changes of living larval zebrafish. We found that developing zebrafish exhibit a transition from the embryonic-type to the adult-type pattern of body color change. Selective ablation of retinal rod and cone photoreceptor cells did not affect the profile of larval body color change, suggesting that unidentified non-rod non-cone retinal neurons are responsible for this photoreaction.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (12 results) Book (4 results) Remarks (3 results)

  • [Journal Article] (*equal contribution; #corresponding authors)UV-sensitive photoreceptor protein OPN5 in humans and mice2011

    • Author(s)
      Kojima,D.*#, Mori,S.*, Torii,M.*, Wada,A., Morishita,R. & Fukada,Y.#
    • Journal Title

      PLoS One

      Volume: 6 Issue: 10 Pages: e26388-e26388

    • DOI

      10.1371/journal.pone.0026388

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (*equal contribution; #corresponding authors) Ectopic expression of the cone-specific Gprotein-coupled receptor kinase GRK7 in zebrafish rods leads to decreased photosensitivity and compromised visual performance2011

    • Author(s)
      Vogalis,F., Shiraki,T., Kojima,D., Fukada,Y. & Lamb,T.
    • Journal Title

      J. Physiol. (London)

      Volume: 589 Issue: 9 Pages: 2321-2348

    • DOI

      10.1113/jphysiol.2010.204156

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses.2011

    • Author(s)
      Fivos Vogalis, Tomoya Shiraki, Daisuke Kojima (同等に貢献)
    • Journal Title

      J.Physiol.(London)

      Volume: 589 Pages: 2321-2348

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced body color change in developing zebrafish2010

    • Author(s)
      Shiraki,T., Kojima,D. and Fukada,Y
    • Journal Title

      Photochem.Photobiol. Sci.

      Volume: 9 Issue: 11 Pages: 1498-1504

    • DOI

      10.1039/c0pp00199f

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced body color change in developing zebrafish.2010

    • Author(s)
      Tomoya Shiraki
    • Journal Title

      Photochem.Photobiol.Sci.

      Volume: 9 Pages: 1364-1371

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ゼブラフィッシュの飼育2010

    • Author(s)
      小島大輔
    • Journal Title

      比較生理生化学 27

      Pages: 28-31

    • NAID

      10029409140

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      小島大輔
    • Journal Title

      動物の多様な生き方 第1巻「見える光、見えない光:動物と光のかかわり」(分担執筆)(共立出版)

      Pages: 209-221

    • Related Report
      2009 Annual Research Report
  • [Presentation] 視覚の光受容細胞における感度調節とノイス低減の分子機構。視覚と嗅覚における似て非なる神経機構のリサーチフロント2011

    • Author(s)
      小島大輔
    • Organizer
      日本動物学会第82回大会シンポジウム
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 視覚の光受容細胞における感度調節とノイス低減の分子機構2011

    • Author(s)
      小島大輔
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Non-visual photoreception in vertebrates, in the symposium "Evolutionary Biochemistry and Physiology of Photoreception in Animals."2011

    • Author(s)
      Daisuke Kojima
    • Organizer
      The 8th International Congress of Comparative Physiology and Biochemistry(ICCPB2011)
    • Place of Presentation
      Nagoya, JAPAN
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Non-visual photoreception in vertebrates2011

    • Author(s)
      Daisuke Kojima
    • Organizer
      The 8th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] UV-sensitive non-visual opsin in mammals2011

    • Author(s)
      Daisuke Kojima
    • Organizer
      FASEB Summer Research Conference : The Biology and Chemistry of Vision
    • Place of Presentation
      Carefree, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゼブラフィッシュの体色変化を制御する光センサーの探索。シンポジウム「光感覚系の進化と多様性:仕組みと意義」2010

    • Author(s)
      小島大輔
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ゼブラフィッシュの体色変化を制御する光センサーの探索2010

    • Author(s)
      小島大輔
    • Organizer
      日本動物学会第81回大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Light-induced body color change in the transgenic zebrafish conditionally lacking retinal rod and cone photoreceptors2010

    • Author(s)
      Daisuke Kojima, Sho Matsumoto, Tomoya Shiraki, Yoshitaka Fukada
    • Organizer
      The 9th International Conference on Zebrafish Development & Genetics
    • Place of Presentation
      Madison, U. S. A.
    • Year and Date
      2010-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Light-induced body color change in the transgenic zebrafish conditionally lacking retinal rod and cone photoreceptors.2010

    • Author(s)
      Daisuke Kojima
    • Organizer
      The 9th International Conference on Zebrafish Development & Genetics
    • Place of Presentation
      Madison, USA
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゼブラフィッシュの体色変化を制御する光センサーの探索2010

    • Author(s)
      小島大輔
    • Organizer
      分子研研究会「拡がるロドプシンの仲間から何がわかるか・何をもたらすか」
    • Place of Presentation
      岡崎
    • Year and Date
      2010-03-24
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 視細胞をコンディショナルに欠損する遺伝子組換えゼブラフィッシュ2009

    • Author(s)
      小島大輔
    • Organizer
      第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 視細胞をコンディショナルに欠損する遺伝子組換えゼブラフィッシュの体色変化2009

    • Author(s)
      松本翔
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Book] ウニ,ナマコから脊椎動物へ2012

    • Author(s)
      小島大輔
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Book] 研究者が教える動物飼育(日本比較生理生化学会編)、分担執筆2012

    • Author(s)
      小島大輔
    • Publisher
      共立出版(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 比較生理科学2010

    • Author(s)
      小島大輔
    • Related Report
      2011 Final Research Report
  • [Book] 見える光、見えない光:動物と光のかかわり2009

    • Author(s)
      小島大輔
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ(研究成果の公開)

    • URL

      http://www.biochem.s.u-tokyo.ac.jp/fukada-lab/research-highlights/rh2008/shiraki2010-j.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biochem.s.u-tokyo.ac.jp/fukada-lab/research-highlights/rh2008/shiraki2010-j.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.biochem.s.u-tokyo.ac.jp/fukada-lab/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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