Identification of sphingosine 1-phosphate transporters and their roles in various physiological functions.
| Project/Area Number |
21570137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
NISHI Tsuyoshi 大阪大学, 産業科学研究所, 准教授 (60403002)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 脂質メディエーター / 輸送体 / スフィンゴシン 1 リン酸 / 赤血球 / 血小板 / 血管内皮細胞 / スフィンゴシン1リン酸 / SPNS2 / 阻害剤 / リソソーム / ATP / 細胞遊走 / 細胞膜 / 血球細胞 / 組織発現 / オーファン輸送体 |
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| Research Abstract |
Sphingosine 1-phosphate (S1P) is a lipid mediator which was secreted from vascular endothelial cells by SPNS2. SPNS2 homologues, SPNS1 and SPNS3, were localized at intracellular compartment and not function as a S1P exporter from the cells. We also develop a novel S1P analogue which functions as a light induced cross-linking to SPNS2. This compound would be useful for identification of erythrocyte S1P transportr(s).
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Report
(5 results)
Research Products
(69 results)
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[Journal Article] The sphingosine 1-phosphate transporter, Spns2 function as an exporter for the phosphorilated form of immunomodulating agent FTY720 from the cells.2011
Author(s)
Hisano, Y., Kobayashi, N., Kawahara, A., Yamaguchi, A., Nishi, T.
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Journal Title
J.Biol.Chem
Volume: 286
Pages: 1758-1766
Related Report
Peer Reviewed
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[Journal Article] Macrophage Abca5influences cellular cholesterol efflux and increases susceptibility to atheroscrosis in female Ldlr knockout mice.2010
Author(s)
Ye, D., Meurs, I., Ohigashi, M., Zhao, Y., Habets, K.LL., Calpe-Berdiel, L., Kubo, Y., Yamaguchi A, van Beckel, T.J.C., Nishi T.and van Eck, M.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 395
Pages: 387-394
Related Report
Peer Reviewed
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