| Project/Area Number |
21570140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasushi 岡山大学, 大学院・自然科学研究科, 教授 (40091251)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKIGUCHI Takeshi 九州大学, 大学院・医学研究院, 助教 (60187846)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞内タンパク質分解・ユビキチン / プロテアソーム / 出芽酵母 / ユビキチン依存タンパク質分解 / UBL-UBAタンパク質 / ポリユビキチン鎖 / タンパク質分解 / ユビキチン / プロテアーゼ / スモールGタンパク / タンパク質 / Gタンパク質 / ストレス応答 |
|---|
| Research Abstract |
Ubiquitin-dependent protein degradation regulates the recognition and delivery of degradable proteins in various cellular functions including the cell cycle. To understand a functional role of UBL-UBA protein, yeast protein Dsk2, which is involved in the delivery process of protein degradation, we identified the Dsk2-interacting proteasome subunits and its accessory factors and analyzed their cellular functions. In this study, as a result, we clarified the regulatory function of UBL-UBA protein in the delivery system of the ubiquitin-proteasome pathway.
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