Investigation and application of virus receptors for infection control by chemical probes regulating glycan function

• Project/Area Number: 21570146
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: University of Shizuoka
• Principal Investigator: HIDARI Kazuya 静岡県立大学, 薬学部, 准教授 (20260226)
• Co-Investigator(Renkei-kenkyūsha): IKEDA Kiyoshi 広島国際大学, 薬学部, 教授 (40168125) ; YAMANAKA Takashi 日本中央競馬会, 競走馬総合研究所, 研究員 (40446513) ; KAN Toshiyuki 静岡県立大学, 薬学部, 教授 (10221904) ; MURATA Takeomi 静岡大学, 農学部, 准教授 (30273171) ; MORITA Kouichi 長崎大学, 熱帯医学研究所, 教授 (40182240)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 糖鎖生物学 / ウイルス / 感染症 / 受容体 / 分子間相互作用 / デングウイルス / 糖鎖 / マイクロドメイン / インフルエンザウイルス

Research Abstract

In order to elucidate molecular function of virus receptors and mechanisms on progression of virus-infectious diseases, we generated a new monoclonal antibody specific for virus glycan receptor, which would contribute to elucidation of tissue distribution of the virus receptor. Artificial glycans and carbohydrate derivatives that competitively inhibited virus-glycan receptor interaction are used to establish a sensitive analysis method for virus adsorption properties. In addition, we newly found glycosphingolipids involved in progression of virus-infectious diseases.

Research Products

• [Journal Article] Antiviral agents targeting glycans on dengue virus E-glycoprotein (2011)
  • Author(s): K. I. P. J. Hidari, T. Suzuki
  • Journal Title: Expert. Rev. Anti. Infect. Ther Volume: 9 Pages: 983-985
  • Peer Reviewed
• [Journal Article] Dengue virus receptor (2011)
  • Author(s): K. I. P. J. Hidari, T. Suzuki
  • Journal Title: Trop. Med. Health Volume: 39 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus (2011)
  • Author(s): J. Chen, S. Yamada, Y. Hama, A. K. Shetty, T. Kobayashi, H. Oda, K. Seiki, E. Kim, T. Kimura, N. Takahashi, Kazuya I. P. J. Hidari, T. Suzuki, Y. Suzuki, K. Sugahara
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 412 Pages: 136-142
  • Peer Reviewed
• [Journal Article] Dengue virus type 2 recognizes carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells (2011)
  • Author(s): S. Wichit, A. Jittmittraphap, K. I. P. J. Hidari, B. Thaisomboonsuk, S. Petmitr, S. Ubol, C. Aoki, S. Itonori, K. Morita, T. Suzuki, Y. Suzuki, W. Jampangern
  • Journal Title: Microbiol. Immunol Volume: 55 Pages: 135-140
  • NAID: 10031121452
  • Peer Reviewed
• [Journal Article] Distribution of influenza virus sialoreceptors on upper and lower respiratory tract in horses and dogs (2011)
  • Author(s): Masanori Muranaka, Takashi Yamanaka, Yoshinari katayama, Kazuya I. P. J. Hidari, Hiroaki Kanazawa, Takashi Suzuki, Kazuomi Oku, Toshifumi Oyamadai
  • Journal Title: J. Vet. Med. Sci Volume: 73 Pages: 125-127
  • NAID: 130000342614
  • Peer Reviewed
• [Journal Article] Antiviral agents targeting glycans on dengue virus E-glycoprotein (2011)
  • Author(s): Kazuya I.P.J.Hidari, Takashi Suzuki
  • Journal Title: Expert Rev.Anti.Infect.Ther. Volume: 9 Pages: 983-985
  • Peer Reviewed
• [Journal Article] Dengue virus receptor (2011)
  • Author(s): Kazuya I.P.J.Hidari, Takashi Suzuki
  • Journal Title: Trop.Med.Health. Volume: 39 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus (2011)
  • Author(s): Jiancheng Chen, Shuhei Yamada, Yoshiki Hama, Ajaya Kumar Shetty, Takanari Kobayashi, Hiroshi Oda, Kosuke Seiki, Eunmi Kim, Takashi Kimura, Naonori Takahashi, Kazuya I.P.J.Hidari, Takashi Suzuki, YasuSuzuki, Kazuyuki Sugahara
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 412 Pages: 136-142
  • Peer Reviewed
• [Journal Article] Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells (2011)
  • Author(s): Wichit S, その他11名
  • Journal Title: Microbiol Immunol Volume: 55 Issue: 2 Pages: 135-140
  • DOI: 10.1111/j.1348-0421.2010.00293.x
  • Peer Reviewed
• [Journal Article] Distribution of influenza virus sialoreceptors on upper and lower respiratory tract in horses and dogs (2011)
  • Author(s): Masanori Muranaka, Takashi Yamanaka, Yoshinari katayama, Kazuya I.P.J.Hidari, Hiroaki Kanazawa, Takashi Suzuki, Kazuomi Oku, Toshifumi Oyamadai
  • Journal Title: J.Vet.Med.Sci. Volume: 73 Pages: 125-127
  • NAID: 130000342614
  • Peer Reviewed
• [Journal Article] Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein (2010)
  • Author(s): D. Kato, I. Watanabe, M. Arihara, N. Sugiura, K. Kimata, Y. Suzuki, K. Morita, K. I. P. J. Hidari, T. Suzuki
  • Journal Title: Antiviral Res Volume: 88 Pages: 236-243
  • Peer Reviewed
• [Journal Article] Infectivity and pathogenicity of canine H3N8 influenza A virus in horses (2010)
  • Author(s): T. Yamanaka, K. Tsujimura, T. Kondo, T. Matsumura, H. Ishida, M. Kiso, K. I. P. J. Hidari, T. Suzuki
  • Journal Title: Influenza Other Respi Volume: 4 Pages: 345-351
  • Peer Reviewed
• [Journal Article] Glycan receptor for influenza virus (2010)
  • Author(s): K. I. P. J. Hidari, T. Suzuki
  • Journal Title: Open Antimicrob. Agents J Volume: 2 Pages: 26-33
  • Peer Reviewed
• [Journal Article] Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein. (2010)
  • Author(s): Daisuke Kato, Shota Era, Ippei Watanabe, Masataka Arihara, Nobuo Sugiura, Koji Kimata, Yasuo Suzuki, Kouichi Morita, Kazuya I.P.J.Hidari, Takashi Suzuki
  • Journal Title: Antiviral Res. Volume: 88 Pages: 236-243
  • Peer Reviewed
• [Journal Article] Infectivity and pathogenicity of canine H3N8 influenza A virus in horses. (2010)
  • Author(s): Takashi Yamanaka, Koji Tsujimura, Takashi Kondo, Tomio Matsumura, Hideharu Ishida, Makoto Kiso, Kazuya I.P.J.Hidari, Takashi Suzuki
  • Journal Title: Influenza Other Respi.Viruses Volume: 4 Pages: 345-351
  • Peer Reviewed
• [Journal Article] Glycan receptor for influenza virus. (2010)
  • Author(s): Kazuya I.P.J.Hidari, Takashi Suzuki
  • Journal Title: Open Antimicobial Agents J. Volume: 2 Pages: 26-33
  • Peer Reviewed
• [Journal Article] Structure and function of glycoconjugates involved in dengue virus infection. (2010)
  • Author(s): Kazuya I.P.J.Hidari, Takashi Suzuki
  • Journal Title: Seikagaku Volume: 82 Pages: 751-755
  • NAID: 10027502423
• [Journal Article] Molecular design of spacer-N-linked sialoglycopolypeptide as polymeric inhibitors against influenza virus infection (2009)
  • Author(s): M. Ogata, K. I. P. J. Hidari, W. Kozaki, T. Murata, J. Hiratake, E. Y. Park, T. Suzuki, T. Usui
  • Journal Title: Biomacromolecules Volume: 10 Pages: 1894-1903
  • Peer Reviewed
• [Journal Article] Identification and characterization of flavonoids as sialyltransferase inhibitors (2009)
  • Author(s): K. I. P. J. Hidari, K. Oyama, G. Ito, M. Nakayama, M. Inai, S. Goto, Y. Kanai, K. Watanabe, K. Yoshida, T. Furuta, T. Kan, T. Suzuki
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 382 Pages: 609-613
  • Peer Reviewed
• [Journal Article] Chemoenzymatic synthesis of sialoglycopolypeptides as glycomimetics to block infection by avian and human influenza viruses (2009)
  • Author(s): K. I. P. J. Hidari, M. Ogata, T. Murata, S. Shimada, W. Kozaki, E. Y. Park, T. Suzuki, T. Usui
  • Journal Title: Bioconjugate Chem Volume: 20 Pages: 538-549
  • Peer Reviewed
• [Journal Article] Systematic syntheses ofinfluenza neuraminidase inhibitors : A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties (2009)
  • Author(s): J. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I. P. J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, T. Nakamura, K. Hatano, D. Terunuma, K. Matsuoka
  • Journal Title: Bioorg. Med. Chem Volume: 17 Pages: 5451-5464
  • Peer Reviewed
• [Journal Article] Molecular design of spacer-N-linked sialoglycopolypeptide as polymeric inhibitors against influenza virus infection (2009)
  • Author(s): Makoto Ogata, Kazuya I.P.J.Hidari, Wataru Kozaki, Takeomi Murata, Jun Hiratake, Enoch Y.Park, Takashi Suzuki, Taichi Usui
  • Journal Title: Biomacromolecules 10 Pages: 1894-1903
  • Peer Reviewed
• [Journal Article] Identification and characterization of flavonoids as sialyltransferase inhibitors (2009)
  • Author(s): Kazuyal I.P.J.Hidari, Kin-ichi.Oyama, Go Ito, Miho Nakayama, Makoto Inai, Shiho Goto, Yugo Kanai, Kei-ichi Watanabe, Kumi Yoshida, Takumi Furuta, Toshiyuki Kan, Takashi Suzuki
  • Journal Title: Biochem.Biophys.Res.Commun. 382 Pages: 609-613
  • Peer Reviewed
• [Journal Article] Chemoenzymatic synthesis of sialoglycopolypeptides as glycomimetics to block infection by avian and human influenza viruses (2009)
  • Author(s): Kazuya I.P.J.Hidari, Makoto Ogata, Takeomi Murata, Shizumi Shimada, Wataru Kozaki, Enoch Y.Park, Takashi Suzuki, Taichi Usui
  • Journal Title: Bioconjugate Chem. 20 Pages: 538-549
  • Peer Reviewed
• [Journal Article] Systematic syntheses of influenza neuraminidase inhibitors : A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties (2009)
  • Author(s): Jun-Ichi Sakamoto, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I.P.J.Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Yasuaki Esumi, Takemichi Nakamura, Ken Hatano, Daiyo Terunuma, Koji Matsuoka
  • Journal Title: Bioorg.Med.Chem. 17 Pages: 5451-5464
  • Peer Reviewed
• [Presentation] イヌインフルエンザウイルスの異種間感染に関わるシアロ糖鎖 (2012)
  • Author(s): 吉野宏毅、左一八、南島陽平、山中隆史、尾形慎、村田健臣、碓氷泰市、三輪好伸、山田俊博、鈴木隆
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] インフルエンザウイルス受容体を認識する新規Siaα2-3結合型シアロ糖鎖検出プローブ (2012)
  • Author(s): 山口真帆、左一八、鈴木隆
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] デングウイルスEタンパク質機能を阻害する低分子糖誘導体 (2012)
  • Author(s): 左一八、渡邊一平、安倍智子、池田潔、山藤歩、常盤広明、森田公一、鈴木隆
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] Sulfated Glucuronide Derivative As A Potential Anti-dengue Virus Agent. (2011)
  • Author(s): K. I. P. J. Hidari
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium Program and Abstracts
  • Place of Presentation: Tokyo
  • Year and Date: 2011-12-30
• [Presentation] Sulfated Glucuronide Derivative As A Potential Anti-dengue Virus Agent (2011)
  • Author(s): Kazuya I.P.J.Hidari, Tomoko Abe, Maiko Takano, Ippei Watanabe, Kiyosi Ikeda, Kouichi Morita, Takashi Suzuki
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2011-11-30
• [Presentation] A monoclonal antibody recognizes sialo-glycans with Siaα2-3 Glycans. (2011)
  • Author(s): K. I. P. J. Hidari
  • Organizer: The 4th International Conference on Health and Longevity Sciences Program and Abstracts
  • Place of Presentation: Shizuoka
  • Year and Date: 2011-10-21
• [Presentation] デングウイルスEタンパク質を標的とする抗ウイルス剤の創製 (2011)
  • Author(s): 左一八
  • Organizer: USフォーラム2011
  • Place of Presentation: 静岡
  • Year and Date: 2011-09-27
• [Presentation] 新規Siaα2-3結合型糖鎖検出プローブの確立 (2011)
  • Author(s): 山口真帆
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Biochemical properties of N-linked glycosylation of dengue virus NS1 protein (2011)
  • Author(s): K. Ekawa
  • Organizer: International Union of Microbiological Societies 2011 Congress(IUMS2011, Sapporo)
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-15
• [Presentation] Biochemical properties of N-linked glycosylation of dengue virus NS1 protein (2011)
  • Author(s): Katsuki Ekawa, Kazuya I.P.J.Hidari, Kouichi Morita, Takashi Suzuki
  • Organizer: International Union of Microbiological Societies 2011 Congress (IUMS2011)
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-15
• [Presentation] Siaα2-3含有糖鎖の免疫学的検出 (2011)
  • Author(s): 江川且起
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
  • Year and Date: 2011-07-13
• [Presentation] デングウイルスNS1タンパク質糖鎖の性状解析 (2011)
  • Author(s): 江川且起、左一八、森田公一、鈴木隆
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
  • Year and Date: 2011-07-13
• [Presentation] デングウイルスEタンパク質機能を標的とする低分子糖誘導体 (2011)
  • Author(s): 左一八
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
  • Year and Date: 2011-07-11
• [Presentation] Siaα2-3含有糖鎖の免疫学的検出 (2011)
  • Author(s): 江川且起
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-09
• [Presentation] デングウイルスNS1タンパク質の糖鎖修飾 (2011)
  • Author(s): 江川且起、左一八、森田公一、鈴木隆
  • Organizer: 第57回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-09
• [Presentation] Siaα2-3含有糖鎖の免疫学的検出 (2011)
  • Author(s): 左一八
  • Organizer: 第25回インフルエンザ研究者交流の会シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2011-06-03
• [Presentation] Siaα2-3含有糖鎖の免疫学的検出 (2011)
  • Author(s): 山口真帆
  • Organizer: 第75回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2011-05-28
• [Presentation] デングウイルスNS1タンパク質糖鎖の生化学的性状 (2011)
  • Author(s): 江川且起
  • Organizer: 第75回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2011-05-28
• [Presentation] イヌから分離されたA型インフルエンザウイルスのシアロ糖鎖認識 (2011)
  • Author(s): 吉野宏毅
  • Organizer: 第75回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2011-05-28
• [Presentation] 病原性の異なる日本脳炎ウイルス株の硫酸化糖鎖認識 (2011)
  • Author(s): 左一八
  • Organizer: 第46回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 金沢
  • Year and Date: 2011-05-20
• [Presentation] デングウイルスEタンパク質機能を阻害する低分子誘導体 (2011)
  • Author(s): 左一八
  • Organizer: 第46回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 金沢
  • Year and Date: 2011-05-20
• [Presentation] 病原性の異なる日本脳炎ウイルス株の硫酸化糖鎖認 (2011)
  • Author(s): 左一八、田島茂、高崎智彦、倉根一郎、森田公一、鈴木隆
  • Organizer: 第46回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 金沢
  • Year and Date: 2011-05-20
• [Presentation] デングウイルス結合性硫酸化糖鎖分子の同定と感染制御への応用 (2011)
  • Author(s): 左一八
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] デングウイルス結合性硫酸化糖鎖分子の同定と感染制御への応用 (2011)
  • Author(s): 左一八、渡辺一平、在原雅貴、杉浦信夫、木全弘治、森田公一、鈴木隆
  • Organizer: 第53回日本脂質生化学会(東京)
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] デングウイルス結合性硫酸化糖鎖分子の構造と性状解析 (2011)
  • Author(s): 神邊友宏
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-31
• [Presentation] イヌインフルエンザウイルスのシアロ糖鎖認識機構 (2011)
  • Author(s): 吉野宏毅
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-31
• [Presentation] ウイルス侵入過程を標的とする糖鎖性抗デングウイルス剤の創出 (2011)
  • Author(s): 江良翔太、左一八、渡辺一平、池田潔、杉浦信夫、木全弘治、森田公一、鈴木隆
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-31
• [Presentation] 病原性の異なる日本脳炎ウイルス株の硫酸化糖鎖認識 (2011)
  • Author(s): 須藤豊
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 大腸菌を宿主とする組換え体シアル酸転移酵素発現系の構築 (2011)
  • Author(s): 渡邊圭一
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] インフルエンザウイルスが認識する宿主受容体糖鎖 (2011)
  • Author(s): 左一八
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-29
• [Presentation] デングウイルスEタンパク質を標的とする低分子侵入阻害剤 (2010)
  • Author(s): 江良翔太、左一八、渡辺一平、池田潔、杉浦信夫、木全弘治、森田公一、鈴木隆
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-08
• [Presentation] Anti-viral activity of marine sulfated polysaccharide targeting dengue virus envelope protein (2010)
  • Author(s): Kazuya I.P.J.Hidari, Takashi Suzuki
  • Organizer: 3rd International Conference on Health and Longevity Sciences
  • Place of Presentation: Shizuoka
  • Year and Date: 2010-10-16
• [Presentation] Expression and purification of soluble recombinant human ST6Gal I (2010)
  • Author(s): Kei-ichi Watanabe, Kazuya I.P.J.Hidari, Takashi Suzuki
  • Organizer: 3rd International Conference on Health and Longevity Sciences
  • Place of Presentation: Shizuoka
  • Year and Date: 2010-10-16
• [Presentation] デングウイルスE糖タンパク質を標的とするウイルス侵入阻害 (2010)
  • Author(s): 江良翔太、左一八、渡辺一平、池田潔、杉浦信夫、木全弘治、森田公一、鈴木隆
  • Organizer: 糖鎖科学名古屋拠点 第8回若手のカフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-09-06
• [Presentation] Sialoglyco2010 (2010)
  • Author(s): K. Watanabe
  • Organizer: Purification of soluble recombinant human ST6Gal I expressed in E. coli
  • Place of Presentation: Potsdam, Germany
  • Year and Date: 2010-08-22
• [Presentation] Purification of soluble recombinant human ST6Gal I expressed in E.coli (2010)
  • Author(s): Kei-ichi Watanabe, Kazuya I.P.J.Hidari, Takashi Suzuki
  • Organizer: Sialoglyco2010
  • Place of Presentation: Potsdam, Germany
  • Year and Date: 2010-08-22
• [Presentation] Anti-flavi virus activity of sulfated carbohydrates (2010)
  • Author(s): K. I. P. J. Hidari
  • Organizer: 25th International Carbohydrate Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2010-08-05
• [Presentation] 日本脳炎ウイルス感染における硫酸化糖鎖分子の構造と機能 (2010)
  • Author(s): 左一八
  • Organizer: 第45回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-28
• [Presentation] Anti-Dengue Virus Activity of Sulfated Polysaccharides (2009)
  • Author(s): K. I. P. J. Hidari
  • Organizer: Duke-NUS Emerging Infectious Diseases Inauguration Symposium & 4th Asian Dengue Research Network Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2009-12-09
• [Presentation] 硫酸化糖鎖を介したデングウイルス-宿主細胞間相互作用 (2009)
  • Author(s): 左一八
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] 硫酸化糖鎖を介したデングウイルス―宿主細胞間相互作用 (2009)
  • Author(s): 左一八
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Bacterial expression of recombinant human sialyltransferase, ST6GaI I (2009)
  • Author(s): Kazuya I.P.J.Hidari
  • Organizer: 2nd International Conference on Health and Longevity Sciences
  • Place of Presentation: Shizuoka city
  • Year and Date: 2009-10-01
• [Presentation] インフルエンザウイルスヘマグルチニン-受容体糖鎖間相互作用の分子機構 (2009)
  • Author(s): 南島陽平
  • Organizer: 糖鎖科学名古屋拠点第7回若手の力
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-30
• [Presentation] インフルエンザウイルスヘマグルチニン―受容体糖鎖間相互作用の分子機構 (2009)
  • Author(s): 南島陽平
  • Organizer: 糖鎖科学名古屋拠点 第7回若手のカフォーラム
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-30
• [Presentation] フラビウイルス感染に関わる硫酸化糖鎖分子の構造と機能 (2009)
  • Author(s): 左一八
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
  • Year and Date: 2009-09-11
• [Presentation] フラビウイルス感染に関わる硫酸化糖鎖分子の構造と機能 (2009)
  • Author(s): 左一八
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山市
  • Year and Date: 2009-09-11
• [Presentation] グリコサミノグリカンによるフラビウイルス感染阻害 (2009)
  • Author(s): 渡邊一平
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
  • Year and Date: 2009-09-10
• [Presentation] グリコサミノグリカンによるフラビウイルス感染阻害 (2009)
  • Author(s): 渡邊一平
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山市
  • Year and Date: 2009-09-10
• [Presentation] 細胞表面グリカン生合成阻害剤の探索と阻害作用機序の解明 (2009)
  • Author(s): 左一八
  • Organizer: 2008 USフォーラム
  • Place of Presentation: 静岡市
  • Year and Date: 2009-08-05
• [Presentation] 伸長度の異なるシアロ糖鎖に対するインフルエンザウイルス結合性 (2009)
  • Author(s): 南島陽平
  • Organizer: 第23回インフルエンザ研究者交流の会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-03
• [Presentation] 日本脳炎ウイルス感染における硫酸化糖鎖分子の構造と機能 (2009)
  • Author(s): 左一八
  • Organizer: 第44回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 千歳
  • Year and Date: 2009-06-20
• [Presentation] 日本脳炎ウイルス感染における硫酸化糖鎖分子の構造と機能 (2009)
  • Author(s): 左一八
  • Organizer: 第44回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 千歳市
  • Year and Date: 2009-06-20
• [Presentation] シアル酸転移酵素阻害剤の探索および作用機構 (2009)
  • Author(s): 左一八
  • Organizer: 第73回日本生化学会中部支部例会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-05-23
• [Presentation] シアル酸転移酵素阻害剤の探索および作用機構 (2009)
  • Author(s): 左一八
  • Organizer: 第73回日本生化学会中部支部例会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-05-23
• [Patent(Industrial Property Rights)] 抗デングウイルス剤 (2010)
  • Inventor(s): 鈴木隆、左一八、池田潔
  • Industrial Property Rights Holder: 静岡県公立大学法人、学校法人常翔学園
  • Industrial Property Number: 2010-248271
  • Filing Date: 2010-11-05