| Project/Area Number |
21570146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
HIDARI Kazuya 静岡県立大学, 薬学部, 准教授 (20260226)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Kiyoshi 広島国際大学, 薬学部, 教授 (40168125)
YAMANAKA Takashi 日本中央競馬会, 競走馬総合研究所, 研究員 (40446513)
KAN Toshiyuki 静岡県立大学, 薬学部, 教授 (10221904)
MURATA Takeomi 静岡大学, 農学部, 准教授 (30273171)
MORITA Kouichi 長崎大学, 熱帯医学研究所, 教授 (40182240)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖鎖生物学 / ウイルス / 感染症 / 受容体 / 分子間相互作用 / デングウイルス / 糖鎖 / マイクロドメイン / インフルエンザウイルス |
|---|
| Research Abstract |
In order to elucidate molecular function of virus receptors and mechanisms on progression of virus-infectious diseases, we generated a new monoclonal antibody specific for virus glycan receptor, which would contribute to elucidation of tissue distribution of the virus receptor. Artificial glycans and carbohydrate derivatives that competitively inhibited virus-glycan receptor interaction are used to establish a sensitive analysis method for virus adsorption properties. In addition, we newly found glycosphingolipids involved in progression of virus-infectious diseases.
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