Regulation of CD44-hyaluronan interaction by SHAP and its role in inflammation
Project/Area Number |
21570147
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Aichi Medical University |
Principal Investigator |
ZHUO Lisheng 愛知医科大学, 医学部, 准教授 (00399031)
|
Co-Investigator(Renkei-kenkyūsha) |
KIMATA Koji 愛知医科大学, 名誉教授 (10022641)
BABA Kenji 愛知医科大学, 医学部, 教授 (80211499)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 糖鎖生物学 / SHAP / ヒアルロン酸 / CD44 / 炎症 / 細胞接着 |
Research Abstract |
CD44and its ligand hyaluronan emerge as important adhesion molecules for leucocyte infiltration in inflammatory response. We have found that the serum protein SHAP binds covalently to hyaluronan and enhances the adhesion of CD44-positive cells to hyalurona. In this project, we reveal that SHAP plays significant roles in in vivo inflammatory responses by using SHAP-deficient mice. Depending on the affected organ and disease model, the role of SHAP varies, either being inflammatory(such as in acute liver injury model) or being anti-inflammatory(such as in airway hyper-responsiveness model and intracerebral hemorrhage model).
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice2009
Author(s)
Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW
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Journal Title
J Biol Chem
Volume: 284(17)
Pages: 11309-17
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Peer Reviewed
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[Journal Article]2009
Author(s)
卓麗聖, 木全弘治(田畑泰彦編集)
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Journal Title
ますます重要になる細胞周辺環境の科学技術-細胞の生存、増殖、機能のコントロールから再生医療まで(株式会社メディカルドゥ)
Pages: 195-200
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[Presentation] Hyaluronan plays significant roles not only in maintenance of musculoskeletal systems but also in tumorigenecity of musculoskeletal malignant tumors2010
Author(s)
Nishida Y, Wasa J, Urakawa H, Arai E, Shinomura T, Zhuo L, Kimata K, Knudson W, Knudson C, Ishiguro N
Organizer
HA2010
Place of Presentation
Kyoto, Japan
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