| Project/Area Number |
21570148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
KUROSAKA Akira 京都産業大学, 総合生命科学部, 教授 (90186536)
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| Co-Investigator(Kenkyū-buntansha) |
TERACHI Toru 京都産業大学, 総合生命科学部, 教授 (90202192)
SEO Misuzu 京都産業大学, 総合生命科学部, 教授 (60211223)
NAKAMURA Naosuke 京都産業大学, 工学部, 講師 (30424964)
NAKAYAMA Yoshiaki 京都産業大学, 総合生命科学部, 助教 (40512455)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 糖鎖生物学 / 神経科学 / 糖転移酵素 / アポトーシス / RNAi / ゼブラフィッシュ / マクロピノサイトーシス / 神経発生 |
|---|
| Research Abstract |
The purpose of this study is to clarify the roles of mucin-type carbohydrates and glycosyltransferases involved in their biosynthesis in neural development. We investigated the functions of WBSCR17, a brain-specific isozyme, and mucin-type carbohydrates in mouse embryonic carcinoma P19 cells, which can differentiate into neural cells, and human embryonic kidney HEK293T cells. Also the roles of WBSCR17 in neural differentiation in zebrafish were examined. Through these studies, we elucidated that WBCSR17 is involved in the neural development and membrane trafficking in the cells.
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