Molecular basis of the regulation of adipogenesis by lipid mediators
| Project/Area Number |
21570151
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Osaka University of Pharmaceutical Sciences |
|---|
Principal Investigator |
FUJIMORI Ko 大阪薬科大学, 薬学部, 講師 (70425453)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARITAKE Kosuke 大阪バイオサイエンス研究所, 分子行動生物学部門, 研究員 (70390804)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 脂質メディエーター / プロスタグランジン / 肥満 / 分化制御 / 脂肪細胞 |
|---|
| Research Abstract |
Prostaglandin(PG) E_2 and PGF_<2α>, members of lipid mediators, are synthesized by microsomal PGE synthase-1 and aldo-keto reductase 1B3, respectively, in adipocytes, and synergistically suppress the progression of the early phase of adipogenesis. Moreover, these PGE_2 and PGF_<2α> enhance the expression of cyclooxygenase-2 gene through their EP4 and FP receptors. We also found thatΔ^<12>-PGJ_2, one of PGD_2 metabolites, activates the adipogenesis.
|
Report
(4 results)
Research Products
(103 results)
-
-
-
[Journal Article] Lipocalin-type Prostaglandin D Synthase Protects Against Oxidative Stress-induced Neuronal Cell Death2012
Author(s)
Fukuhara, A., Yamada, M., Fujimori, K., Miyamoto, Y., Kusumoto, T., Nakajima, H., Inui, T.
-
Journal Title
Biochemical Journal
Volume: 443
Issue: 1
Pages: 75-84
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Adipokine ganglioside GM2 activator protein stimulates insulin secretion2011
Author(s)
Higashi, K., Kubo, H., Watanabe, H., Fujimori, K., Mikami, T., and Kaneko, H
-
Journal Title
FEBS Lett
Volume: 585
Issue: 16
Pages: 2587-2591
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F_<2α> synthase2010
Author(s)
Fujimori, K., Ueno, T., Nagata, N., Kashiwagi, K., Aritake, K., Amano, F., and Urade, Y
-
Journal Title
J. Biol. Chem
Volume: 285
Pages: 8880-8886
Related Report
Peer Reviewed
-
[Journal Article] Pronounced adipogenesis and increased insulin sensitivity by overproduction of prostaglandin D_2 in vivo2010
Author(s)
Fujitani, Y., Aritake, K., Kanaoka, Y., Goto, T., Takahashi, N., Fujimori, K., and Kawada, T
-
Journal Title
FEBS J
Volume: 277
Issue: 6
Pages: 1410-1419
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] De novo synthesis, uptake, and proteolytic processing of lipocalin-type prostaglandin D synthase, ss-trace, in the kidneys2009
Author(s)
Nagata, N., Fujimori, K., Okazaki, I., Oda, H. Eguchi, N.; Uehara, Y., and Urade, Y
-
Journal Title
FEBS J
Volume: 276
Pages: 7146-7158
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
