| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We compared protective mechanisms of nicotine and NGF(nerve growth factor) against ER stress in PC12 cells as a model neuron. Nicotine suppressed ER stress at the earliest stage, but NGF protected it through enhanced expression of ER chaperon GRP78. In addition, forskolin which increases cAMP level protected it at the earliest stage as nicotine. Therefore, the treatment of cells with all three compounds(or factors) is considered to have an additive or cooperative protective effect against neuronal ER stress.
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