Collective migration of epithelial cells induced by softness of substrates
| Project/Area Number |
21570158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Hokkaido University |
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Principal Investigator |
HAGA Hisashi 北海道大学, 大学院・先端生命科学研究院, 准教授 (00292045)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Kazushige 北海道大学, 大学院・先端生命科学研究院, 教授 (20261274)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 上皮細胞 / 細胞運動 / 集団性 / メカノセンス / コラーゲンゲル / 接着構造 / 集団運動 / ゲル基質 |
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| Research Abstract |
Cell movement plays an important role in many physiological processes, including wound healing, embryonic development, and morphogenesis. In this study, we observed that epithelial cells (Madin-Darby canine kidney cell) migrated collectively along one direction on a soft substrate. Cell-substrate adhesions, cell-cell mechanotransduction, and appearance of leader cells were studied.
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Report
(4 results)
Research Products
(33 results)
