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A Study on the multiplicity and hierarchical control of the mechanism for learning and memory

Research Project

Project/Area Number 21570161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics
Research InstitutionUniversity of Toyama

Principal Investigator

KAWAHARA Shigenori  富山大学, 大学院・理工学研究部(工学), 教授 (10204752)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳・神経系の情報処理 / 学習 / 記憶 / 階層性 / 代償性 / 瞬目反射条件付け / 小脳 / 海馬 / NMDA受容体
Research Abstract

We investigated the roles of cerebellum and the higher nervous systems in a motor learning task, the classical eyeblink conditioning, in which the basic neural circuit has been elucidated in rabbits. We found that the acquisition and retention of the memory in this task depend on the ipsilateral cerebellum in rats, similarly in rabbits. We also examined the cerebellar dependency in DBA/2 mice, which have an abnormal higher nervous system. DBA/2 mice showed a similar dependency on the ipsilateral cerebellum, which was different from the results reported in C57BL/6 mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (13 results)

  • [Journal Article] Erasing fear memories. key receptor and essential time frame discovere2011

    • Author(s)
      Shigenori Kawahara
    • Journal Title

      Acta Pharmacologica Sinica

      Volume: 32 Pages: 1-2

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Erasing fear memories-key receptor and essential timeframe discoverect.2011

    • Author(s)
      Shigenori Kawahara
    • Journal Title

      Acta Pharmacologica Sinica

      Volume: 32 Pages: 1-2

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ipsilateral cerebellum ablation on acquisition and retention of classically conditioned eyeblink responses in rats2010

    • Author(s)
      Takahiro Horiuchi, Shigenori Kawahara
    • Journal Title

      Neuroscience Letters

      Volume: 472 Pages: 148-152

    • NAID

      120006399295

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ipsilateral cerebellum ablation on acquisition and retention of classically conditioned eyeblink responses in rats.2010

    • Author(s)
      Takahiro Horiuchi, Shigenori Kawahara
    • Journal Title

      Neurosci.Letters 472

      Pages: 148-152

    • NAID

      120006399295

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Image analysis of eyeblink conditioning in mice2011

    • Author(s)
      臼井弘児
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Image analysis of eyeblink conditioning in mice2011

    • Author(s)
      臼井弘児
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC., USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 拘束下マウスにおける古典的瞬目反射条件付けの画像解析2011

    • Author(s)
      臼井弘児
    • Organizer
      海馬と高次脳機能学会
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Eyeblink conditioning in DBA/2 mice depends on the ipsilateral cerebellar nuclei2011

    • Author(s)
      中村陽一
    • Organizer
      日本生物物理学会
    • Place of Presentation
      姫路
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 同側小脳破壊マウスにおける瞬目反射条件応答の獲得と表出へのNMDA受容体の関与2011

    • Author(s)
      佐藤大地
    • Organizer
      日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 文脈依存的瞬目反射弁別学習における海馬シータ波依存性2010

    • Author(s)
      川原茂敬
    • Organizer
      海馬と高次脳機能学会
    • Place of Presentation
      金沢
    • Year and Date
      2010-11-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Roles of the prefrontal cortex and the cerebellum in mice eyeblink conditioning2010

    • Author(s)
      Shigenori Kawahara
    • Organizer
      日本生物物理学会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-01
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ラット瞬目反射学習における同側小脳と対側小脳の役割の違い2010

    • Author(s)
      堀内嵩大
    • Organizer
      日本生物物理学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] マウス瞬目反射条件づけに見られる学習メカニズムの多重性2010

    • Author(s)
      川原茂敬
    • Organizer
      日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Dependence on the cerebellum and the medial prefrontal cortex in mouse eyeblink conditioning2009

    • Author(s)
      Shigenori Kawahara
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Dependence on the cerebellum and the medial prefrontal cortex in mouse eyeblink conditioning2009

    • Author(s)
      Shigenori Kawahara
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス瞬目反射条件付けにおける小脳および内側前頭前野依存性2009

    • Author(s)
      川原茂敬
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] マウスにおける痕跡課題瞬目反射条件付けの画像解析2009

    • Author(s)
      臼井弘児
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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