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Molecular Mechanism of re-isomerization ofretinal in visual cycle

Research Project

Project/Area Number 21570174
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics
Research InstitutionTokushima Bunri University

Principal Investigator

TSUDA Motoyuki  徳島文理大学, 香川薬学部, 客員教授 (60045458)

Co-Investigator(Renkei-kenkyūsha) TERAKITA Akihisa  大阪市立大学, 理学研究科, 教授 (30212062)
KUSAKABE Takehiro  甲南大学, 理工学部, 教授 (40280862)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords視覚サイクル / レチナール / ロドプシン / 異性化 / ホヤ / 光異性化酵素 / 抗体 / 暗異性化酵素
Research Abstract

Absorption of a photon by visual pigments induces isomerization of 11-cis-retinaldehyde(RAL) chromophore to all-trans-RAL. Here we comparevisual retinoid cycles between different photoreceptors of vertebrates as well as invertebrates. The visual cycle systems in ascidians, the closest living relatives of vertebrates, show an intermediate state between vertebrates and non-chordate invertebrates. The ascidian larva may use retinochrome-like opsin as the major isomerase retinal but RPE65 in asidinan did not isomerase retinal. These results are very interesting in the evolutional standpoints.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2012 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (3 results) Book (3 results)

  • [Journal Article] Evidence for differential regulation of GnRH signaling via heterodimerization amongGnRH receptor paralogs in the protochordate2012

    • Author(s)
      T. Sakai, M. Aoyama, T. Kusakabe, M. Tsuda, H. Satake
    • Journal Title

      Ciona, Endocrinology

      Volume: 153 Pages: 1841-1849

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for differential regulation of GnRH signaling via heterodimerization amongGnRH receptor paralogs in the protochordate, Ciona intestinalis2012

    • Author(s)
      T.Sakai, M.Aoyama, T.Kusakabe, M.Tsuda, H.Satake
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 1841-1849

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Diversity of Signaling Pathways through G Protein-CoupledReceptor Heterodimerization with a Species-Specific Orphan Receptor Subtype2010

    • Author(s)
      Sakai, T., Aoyama, M., Kusakabe, K., Tsuda, M., Satake, H
    • Journal Title

      Mol. Biol. Evol

      Volume: 27(5) Pages: 1097-1106

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smith WC, doublesex/mab3 related-1(dmrt1) is essential for development of anterior neural plate derivatives in Ciona2010

    • Author(s)
      Tresser J, Chiba S, Veeman M, El-Nachef D, Newman-Smith E, Horie T, Tsuda M
    • Journal Title

      Development

      Volume: 37(13) Pages: 197-203

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple motor systemof the ascidian larva : neuronal complexcomprising putative cholinergic andGABAergic/glycinergic neurons2010

    • Author(s)
      Horie T, Nakagawa M, Sasakura Y, Kusakabe TG, Tsuda M
    • Journal Title

      Zoolog Sci

      Volume: 27(2) Pages: 181-90

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional Diversity of Signaling Pathways through G Protein-CoupledReceptor Heterodimerization with a Species-Specific Orphan Receptor Subtype2010

    • Author(s)
      Sakai, T., Aoyama,M., Kusakabe, K., Tsuda, M., Satake, H
    • Journal Title

      Mol.Biol.Evol.

      Volume: 27(5) Pages: 1097-1106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] doublesex/mab3 related-1 (dmrt1) is essential for development of anterior neural plate derivatives in Ciona.2010

    • Author(s)
      Tresser J, Chiba S, Veeman M, El-Nachef D, Newman-Smith E, Horie T, Tsuda M, Smith WC
    • Journal Title

      Development

      Volume: 37(13) Pages: 2197-2203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple motor system of the ascidian larva : neuronal complex comprising putative cholinergic and GABAergic/glycinergic neurons.2010

    • Author(s)
      Horie T, Nakagawa M, Sasakura Y, Kusakabe TG, Tsuda M
    • Journal Title

      Zoolog Sci.

      Volume: 27(2) Pages: 181-190

    • NAID

      40017358569

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Diversity of Signaling Pathways through G Protein-CoupledReceptor Heterodimerization with a Species-Specific Orphan Receptor Subtype2010

    • Author(s)
      Sakai, T., Aoyama, M., Kusakabe, K., Tsuda, M., Satake, H
    • Journal Title

      Mol.Biol.Evol. 27(5)

      Pages: 1097-1106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolution and the originof the visual retinoid cycle invertebrates2009

    • Author(s)
      Kusakabe, T., Takimoto, N., Minghao Jin, M., Tsuda, M
    • Journal Title

      Phil. Trans. R. Soc. Lond

      Volume: 364 Pages: 2897-2910

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tube formation by complexcellular processes in Ciona intestinalis notochord2009

    • Author(s)
      Dong, B., Horie, T., Denker, E., Kusakabe, K., Tsuda, M., Smith, W., Jiang, D.
    • Journal Title

      Dev. Biol

      Volume: 330(2) Pages: 237-249

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolution and the origin of the visual retinoid cycle in vertebrates2009

    • Author(s)
      Kusakabe, T., Takimoto, N., Minghao Jin, M., Tsuda, M.
    • Journal Title

      Phil.Trans.R.Soc.Lond. B 364

      Pages: 2897-2910

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tube formation by complex cellular processes in Ciona intestinalis notochord2009

    • Author(s)
      Dong, B., Horie, T., Denker, E., Kusakabe, K., Tsuda, M., Smith, W., Jiang, D.
    • Journal Title

      Dev.Biol. 330(2)

      Pages: 237-249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 視覚サイクルの分子メカニズム2010

    • Author(s)
      津田基之
    • Organizer
      生物物理学会中国四国支部大会
    • Place of Presentation
      松山大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Crystalization of octopus rhodopsin2009

    • Author(s)
      Zang, Kanda, Tsuda,, Kouyama
    • Organizer
      生物物理学会
    • Place of Presentation
      アスティ徳島。徳島市
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Crystalization of octopus rhodopsin2009

    • Author(s)
      Zang, Kanda, Tsuda, Kouyama
    • Organizer
      生物物理学会
    • Place of Presentation
      アスティ徳島、徳島市
    • Related Report
      2011 Final Research Report
  • [Book] 環境生物学.地球環境を守るには2010

    • Author(s)
      針山孝彦、津田基之
    • Total Pages
      261
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Book] 環境生物学2010

    • Author(s)
      針山孝彦、津田基之
    • Total Pages
      258
    • Publisher
      共立出版
    • Related Report
      2010 Annual Research Report
  • [Book] 環境生物学-地球環境を守るには2010

    • Author(s)
      針山孝彦、津田基之
    • Total Pages
      261
    • Publisher
      共立出版
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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